Thamaraiselvi Saravanan
Overview
Explore the profile of Thamaraiselvi Saravanan including associated specialties, affiliations and a list of published articles.
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9
Citations
96
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Recent Articles
1.
Sanzhaeva U, Boyd-Pratt H, Bender P, Saravanan T, Rhodes S, Guan T, et al.
Commun Biol
. 2024 Sep;
7(1):1146.
PMID: 39277687
Microtubules are essential for various cellular processes. The functional diversity of microtubules is attributed to the incorporation of various α- and β-tubulin isotypes encoded by different genes. In this work,...
2.
Yanardag S, Rhodes S, Saravanan T, Guan T, Ramamurthy V
Sci Rep
. 2024 May;
14(1):10498.
PMID: 38714794
Prominin 1 (PROM1) is a pentaspan transmembrane glycoprotein localized on the nascent photoreceptor discs. Mutations in PROM1 are linked to various retinal diseases. In this study, we assessed the role...
3.
Aljammal R, Saravanan T, Guan T, Rhodes S, Robichaux M, Ramamurthy V
Hum Mol Genet
. 2024 Feb;
33(9):802-817.
PMID: 38297980
Mutations in Cytosolic Carboxypeptidase-like Protein 5 (CCP5) are associated with vision loss in humans. To decipher the mechanisms behind CCP5-associated blindness, we generated a novel mouse model lacking CCP5. In...
4.
Moakedi F, Aljammal R, Poria D, Saravanan T, Rhodes S, Reid C, et al.
Hum Mol Genet
. 2023 Jun;
32(17):2735-2750.
PMID: 37384398
Phosphodiesterase-6 (PDE6) is the key phototransduction effector enzyme residing in the outer segment (OS) of photoreceptors. Cone PDE6 is a tetrameric protein consisting of two inhibitory subunits (γ') and two...
5.
Munezero D, Aliff H, Salido E, Saravanan T, Sanzhaeva U, Guan T, et al.
J Biol Chem
. 2023 May;
299(6):104809.
PMID: 37172722
Heat shock protein 90 (HSP90) is an abundant molecular chaperone that regulates the stability of a small set of proteins essential in various cellular pathways. Cytosolic HSP90 has two closely...
6.
Sundar J, Munezero D, Bryan-Haring C, Saravanan T, Jacques A, Ramamurthy V
Hum Mol Genet
. 2020 Jan;
29(3):394-406.
PMID: 31925423
Retinitis pigmentosa (RP) is a debilitating blinding disease affecting over 1.5 million people worldwide, but the mechanisms underlying this disease are not well understood. One of the common models used...
7.
Dilan T, Moye A, Salido E, Saravanan T, Kolandaivelu S, Goldberg A, et al.
J Neurosci
. 2018 Dec;
39(8):1347-1364.
PMID: 30573647
Mutations in the Joubert syndrome-associated small GTPase ARL13B are linked to photoreceptor impairment and vision loss. To determine the role of ARL13B in the development, function, and maintenance of ciliated...
8.
Moye A, Singh R, Kimler V, Dilan T, Munezero D, Saravanan T, et al.
Mol Biol Cell
. 2018 May;
29(13):1590-1598.
PMID: 29718757
The outer segment (OS) of photoreceptor cells is an elaboration of a primary cilium with organized stacks of membranous disks that contain the proteins needed for phototransduction and vision. Though...
9.
Dilan T, Singh R, Saravanan T, Moye A, Goldberg A, Stoilov P, et al.
Hum Mol Genet
. 2017 Nov;
27(2):283-294.
PMID: 29126234
Bardet-Biedl syndrome (BBS) is an autosomal recessive ciliopathy characterized by developmental abnormalities and vision loss. To date, mutations in 21 genes have been linked to BBS. The products of eight...