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Virginia Meyer

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Articles 13
Citations 230
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Recent Articles
1.
Atwood C, Bhutani M, Ospina M, Rowe B, Leigh R, Deuchar L, et al.
Chest . 2022 Apr; 162(2):321-330. PMID: 35405112
Background: Acute exacerbations of COPD (AECOPD) are associated with high morbidity and mortality and frequent readmissions. Research Question: What is the effectiveness of a COPD transition bundle, with and without...
2.
Meyer V, Holden M, Weismiller H, Eaton G, Eaton S, Margittai M
J Biol Chem . 2016 Apr; 291(23):12271-81. PMID: 27080260
Tau fibrils are pathological aggregates that can transfer between neurons and then recruit soluble Tau monomers by template-assisted conversion. The propagation of different fibril polymorphs is thought to be a...
3.
Meyer V, Margittai M
Methods Mol Biol . 2015 Oct; 1345:185-99. PMID: 26453213
Template-assisted propagation of Tau fibrils is essential for the spreading of Tau pathology in Alzheimer's disease. In this process, small seeds of fibrils recruit Tau monomers onto their ends. The...
4.
Tugarinov V, Libich D, Meyer V, Roche J, Clore G
Angew Chem Int Ed Engl . 2015 Sep; 54(38):11157-61. PMID: 26352026
The energetic and volumetric properties of a three-state protein folding system, comprising a metastable triple mutant of the Fyn SH3 domain, have been investigated using pressure-dependent (15) N-relaxation dispersion NMR...
5.
Meyer V, Swanson M, Clouston L, Boratynski P, Stein R, Mchaourab H, et al.
Biophys J . 2015 Mar; 108(5):1213-9. PMID: 25762332
Nitroxide spin labels are used for double electron-electron resonance (DEER) measurements of distances between sites in biomolecules. Rotation of gem-dimethyls in commonly used nitroxides causes spin echo dephasing times (Tm)...
6.
Meyer V, Dinkel P, Rickman Hager E, Margittai M
Biochemistry . 2014 Aug; 53(36):5804-9. PMID: 25153692
The propagation of Tau pathology in Alzheimer's disease (AD) is thought to proceed through templated conversion of Tau protein into fibrils and cell-to-cell transfer of elongation-competent seeds. To investigate the...
7.
Meyer V, Dinkel P, Luo Y, Yu X, Wei G, Zheng J, et al.
Angew Chem Int Ed Engl . 2014 Jan; 53(6):1590-3. PMID: 24453187
Seeded conversion of tau monomers into fibrils is a central step in the progression of tau pathology in Alzheimer's disease and other neurodegenerative disorders. Self-assembly is mediated by the microtubule...
8.
Biller J, Elajaili H, Meyer V, Rosen G, Eaton S, Eaton G
J Magn Reson . 2013 Sep; 236:47-56. PMID: 24056272
Electron spin relaxation times at 295 K were measured at frequencies between 250 MHz and 34 GHz for perdeuterated 2,2,6,6-tetramethyl-4-piperidone-1-oxyl (PDT) in five solvents with viscosities that result in tumbling...
9.
Meyer V, Eaton S, Eaton G
Appl Magn Reson . 2013 Apr; 44(4):509-517. PMID: 23565040
The electron spin relaxation rates for the stable radical DPPH (2,2-diphenyl-1-picrylhydrazyl) doped into polystyrene were studied by inversion recovery and electron spin echo at X-band and Q-band between 20 and...
10.
Siddiqua A, Luo Y, Meyer V, Swanson M, Yu X, Wei G, et al.
J Am Chem Soc . 2012 Jun; 134(24):10271-8. PMID: 22656332
Tau pathology in Alzheimer's disease is intimately linked to the deposition of proteinacious filaments, which akin to infectious prions, have been proposed to spread via seeded conversion. Here we use...