Vincent Sauzeau
Overview
Explore the profile of Vincent Sauzeau including associated specialties, affiliations and a list of published articles.
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43
Citations
1434
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Recent Articles
1.
Anselmino L, Malizia F, Avila A, Cesatti Laluce N, Mamberto M, Zanotti L, et al.
Cells
. 2024 Nov;
13(21.
PMID: 39513883
Colorectal cancer (CRC) is the third most commonly diagnosed type of cancer worldwide and is responsible for numerous deaths. 5-fluorouracil (5-FU) is an effective chemotherapy drug commonly used in the...
2.
Bailly C, Degand C, Laine W, Sauzeau V, Kluza J
Life Sci
. 2024 Feb;
342:122510.
PMID: 38387701
Rac1 is a member of the Rho GTPase family which plays major roles in cell mobility, polarity and migration, as a fundamental regulator of actin cytoskeleton. Signal transduction by Rac1...
3.
Dijoux E, Klein M, Misme-Aucouturier B, Cheminant M, de Carvalho M, Collin L, et al.
Allergy Asthma Immunol Res
. 2023 Apr;
15(2):246-261.
PMID: 37021509
Purpose: Asthma is a frequent chronic inflammatory bronchial disease affecting more than 300 million patients worldwide, 70% of whom are secondary to allergy. The diversity of asthmatic endotypes contributes to...
4.
Hassoun D, Rose L, Blanc F, Magnan A, Loirand G, Sauzeau V
BMJ Open Respir Res
. 2022 Sep;
9(1).
PMID: 36109087
Asthma is a frequent respiratory condition whose pathophysiology relies on altered interactions between bronchial epithelium, smooth muscle cells (SMC) and immune responses. Those leads to classical hallmarks of asthma: airway...
5.
Bailly C, Beignet J, Loirand G, Sauzeau V
Biochem Pharmacol
. 2022 Jul;
203:115180.
PMID: 35853497
Small molecule inhibitors of GTPases are increasingly considered for the treatment of multiple human pathologies. The GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1) plays major roles in vital cellular...
6.
Sauzeau V, Beignet J, Bailly C
Biomedicines
. 2022 Jun;
10(6).
PMID: 35740379
Bladder pathologies, very common in the aged population, have a considerable negative impact on quality of life. Novel targets are needed to design drugs and combinations to treat diseases such...
7.
Dupas T, Pele T, Dhot J, Burban M, Persello A, Aillerie V, et al.
Oxid Med Cell Longev
. 2022 May;
2022:7377877.
PMID: 35633883
50% of patients with heart failure have a preserved ejection fraction (HFpEF). Numerous studies have investigated the pathophysiological mechanisms of HFpEF and have shown that endothelial dysfunction plays an important...
8.
Sauzeau V, Beignet J, Vergoten G, Bailly C
Pharmacol Res
. 2022 Apr;
179:106220.
PMID: 35405309
Despite novel targeted and immunotherapies, the prognosis remains bleak for patients with hepatocellular carcinoma (HCC), especially for advanced and/or metastatic forms. The rapid emergence of drug resistance is a major...
9.
Dilasser F, Rio M, Rose L, Tesse A, Guignabert C, Loirand G, et al.
Br J Pharmacol
. 2022 Jan;
179(13):3418-3429.
PMID: 35064565
Background And Purpose: Pulmonary hypertension (PH) is a multifactorial chronic disease characterized by an increase in pulmonary artery (PA) resistance leading to right ventricle (RV) failure. Endothelial dysfunction and alteration...
10.
Rodriguez-Fdez S, Lorenzo-Martin L, Fabbiano S, Menacho-Marquez M, Sauzeau V, Dosil M, et al.
Biology (Basel)
. 2021 Sep;
10(9).
PMID: 34571735
Vav proteins act as tyrosine phosphorylation-regulated guanosine nucleotide exchange factors for Rho GTPases and as molecular scaffolds. In mammals, this family of signaling proteins is composed of three members (Vav1,...