Vincent P Willard
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Explore the profile of Vincent P Willard including associated specialties, affiliations and a list of published articles.
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16
Citations
513
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Recent Articles
1.
Estes B, Enomoto M, Moutos F, Carson M, Toth J, Eggert P, et al.
Sci Adv
. 2021 Sep;
7(38):eabi5918.
PMID: 34524840
Articular cartilage has unique load-bearing properties but has minimal capacity for intrinsic repair. Here, we used three-dimensional weaving, additive manufacturing, and autologous mesenchymal stem cells to create a tissue-engineered, bicomponent...
2.
Willard V, Leddy H, Palmer D, Wu C, Liedtke W, Guilak F
Stem Cells
. 2021 Aug;
39(11):1447-1456.
PMID: 34427363
Transient receptor potential vanilloid 4 (TRPV4) is a polymodal calcium-permeable cation channel that is highly expressed in cartilage and is sensitive to a variety of extracellular stimuli. The expression of...
3.
Adkar S, Wu C, Willard V, Dicks A, Ettyreddy A, Steward N, et al.
Stem Cells
. 2018 Nov;
37(1):65-76.
PMID: 30378731
The differentiation of human induced pluripotent stem cells (hiPSCs) to prescribed cell fates enables the engineering of patient-specific tissue types, such as hyaline cartilage, for applications in regenerative medicine, disease...
4.
Tang R, Jing L, Willard V, Wu C, Guilak F, Chen J, et al.
Stem Cell Res Ther
. 2018 Mar;
9(1):61.
PMID: 29523190
Background: Intervertebral disc (IVD) degeneration is characterized by an early decrease in cellularity of the nucleus pulposus (NP) region, and associated extracellular matrix changes, reduced hydration, and progressive degeneration. Cell-based...
5.
Adkar S, Brunger J, Willard V, Wu C, Gersbach C, Guilak F
Trends Mol Med
. 2017 Sep;
23(10):917-931.
PMID: 28887050
Arthritis represents a family of complex joint pathologies responsible for the majority of musculoskeletal conditions. Nearly all diseases within this family, including osteoarthritis, rheumatoid arthritis, and juvenile idiopathic arthritis, are...
6.
Brunger J, Zutshi A, Willard V, Gersbach C, Guilak F
Stem Cell Reports
. 2017 May;
8(5):1202-1213.
PMID: 28457885
Chronic inflammatory diseases such as arthritis are characterized by dysregulated responses to pro-inflammatory cytokines such as interleukin-1 (IL-1) and tumor necrosis factor α (TNF-α). Pharmacologic anti-cytokine therapies are often effective...
7.
Brunger J, Zutshi A, Willard V, Gersbach C, Guilak F
Arthritis Rheumatol
. 2016 Nov;
69(5):1111-1121.
PMID: 27813286
Objective: Proinflammatory cytokines such as interleukin-1 (IL-1) are found in elevated levels in diseased or injured tissues and promote rapid tissue degradation while preventing stem cell differentiation. This study was...
8.
Diekman B, Thakore P, OConnor S, Willard V, Brunger J, Christoforou N, et al.
Tissue Eng Part A
. 2014 Dec;
21(7-8):1261-74.
PMID: 25517798
The limited regenerative capacity of articular cartilage contributes to progressive joint dysfunction associated with cartilage injury or osteoarthritis. Cartilage tissue engineering seeks to provide a biological substitute for repairing damaged...
9.
Willard V, Diekman B, Sanchez-Adams J, Christoforou N, Leong K, Guilak F
Arthritis Rheumatol
. 2014 Jul;
66(11):3062-72.
PMID: 25047145
Objective: The discovery of novel disease-modifying drugs for osteoarthritis (OA) is limited by the lack of adequate genetically defined cartilage tissues for application in high-throughput screening systems. We addressed this...
10.
Diekman B, Christoforou N, Willard V, Sun H, Sanchez-Adams J, Leong K, et al.
Proc Natl Acad Sci U S A
. 2012 Nov;
109(47):19172-7.
PMID: 23115336
The development of regenerative therapies for cartilage injury has been greatly aided by recent advances in stem cell biology. Induced pluripotent stem cells (iPSCs) have the potential to provide an...