Chia-Lung Wu
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Explore the profile of Chia-Lung Wu including associated specialties, affiliations and a list of published articles.
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35
Citations
998
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Recent Articles
1.
Tang R, Harasymowicz N, Wu C, Choi Y, Lenz K, Oswald S, et al.
Proc Natl Acad Sci U S A
. 2024 Oct;
121(43):e2402954121.
PMID: 39401356
Obesity is one of the primary risk factors for osteoarthritis (OA), acting through cross talk among altered biomechanics, metabolism, adipokines, and dietary free fatty acid (FA) composition. Obesity and aging...
2.
The G protein-coupled receptor ADGRG6 maintains mouse growth plate homeostasis through IHH signaling
Bian F, Hansen V, Feng H, He J, Chen Y, Feng K, et al.
J Bone Miner Res
. 2024 Sep;
39(11):1644-1658.
PMID: 39236220
The cartilage growth plate is essential for maintaining skeletal growth; however, the mechanisms governing postnatal growth plate homeostasis are still poorly understood. Using approaches of molecular mouse genetics and spatial...
3.
Swarnkar G, Semenkovich N, Arra M, Mims D, Naqvi S, Peterson T, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(7):e2310264121.
PMID: 38319963
Epigenetic regulation plays a crucial role in the pathogenesis of autoimmune diseases such as inflammatory arthritis. DNA hypomethylating agents, such as decitabine (DAC), have been shown to dampen inflammation and...
4.
Geary M, Orner C, Shammas H, Reuter J, Loiselle A, Giordano B, et al.
J Hip Preserv Surg
. 2024 Jan;
10(3-4):158-165.
PMID: 38162262
Osteoarthritis (OA) of the hip is a common and debilitating painful joint disease. However, there is paucity of surgically induced hip OA models in small animals that allow scientists to...
5.
Kenney H, Rangel-Moreno J, Peng Y, Chen K, Bruno J, Embong A, et al.
Front Immunol
. 2023 Sep;
14:1237498.
PMID: 37691918
Introduction: Defective lymphatic drainage and translocation of B-cells in inflamed (Bin) joint-draining lymph node sinuses are pathogenic phenomena in patients with severe rheumatoid arthritis (RA). However, the molecular mechanisms underlying...
6.
Dicks A, Maksaev G, Harissa Z, Savadipour A, Tang R, Steward N, et al.
Elife
. 2023 Feb;
12.
PMID: 36810131
Mutations in the TRPV4 ion channel can lead to a range of skeletal dysplasias. However, the mechanisms by which TRPV4 mutations lead to distinct disease severity remain unknown. Here, we...
7.
Xie S, Choudhari S, Wu C, Abramson K, Corcoran D, Gregory S, et al.
FASEB J
. 2023 Feb;
37(3):e22785.
PMID: 36794668
The epigenome of stem cells occupies a critical interface between genes and environment, serving to regulate expression through modification by intrinsic and extrinsic factors. We hypothesized that aging and obesity,...
8.
Kuhns B, Reuter J, Hansen V, Soles G, Jonason J, Ackert-Bicknell C, et al.
J Orthop Res
. 2022 Dec;
41(7):1517-1530.
PMID: 36463522
Femoroacetabular impingement (FAI) has a strong clinical association with the development of hip osteoarthritis (OA); however, the pathobiological mechanisms underlying the transition from focal impingement to global joint degeneration remain...
9.
Ackerman J, Best K, Muscat S, Pritchett E, Nichols A, Wu C, et al.
Cell Rep
. 2022 Nov;
41(8):111706.
PMID: 36417854
Tendon injuries heal via a scar-mediated response, and there are no biological approaches to promote more regenerative healing. Mouse flexor tendons heal through the formation of spatially distinct tissue areas:...
10.
Dicks A, Steward N, Guilak F, Wu C
Methods Mol Biol
. 2022 Nov;
2598:87-114.
PMID: 36355287
The generation of large quantities of genetically defined human chondrocytes remains a critical step for the development of tissue engineering strategies for cartilage regeneration and high-throughput drug screening. This protocol...