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Vincent Ouellette

Explore the profile of Vincent Ouellette including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 10
Citations 41
Followers 0
Related Specialties
Chemistry
Biochemistry
Biology
Top 10 Co-Authors
Chahrazed Bouzriba
Sebastien Fortin
Atziri Corin Chavez Alvarez
Genevieve Hamel-Cote
Mathieu Gagne-Boulet
Rene C-Gaudreault
Marie-France Cote
Isabelle Laverdiere
Chantale Simard
Sylvie Pilote
Published In
Bioorg Chem
Eur J Med Chem
J Cardiovasc Pharmacol
J Med Chem
RSC Med Chem
Affiliations
Soon will be listed here.
Recent Articles
1.
Toxicity, Half-Life and Antitumor Activity of Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as Novel Antimitotic CYP1A1-Targeted Prodrugs in Female Mouse Models
Chavez Alvarez A, Bouzriba C, Ouellette V, Gagne-Boulet M, Patenaude A, Pilote S, et al.
Pharmaceutics . 2025 Feb; 17(2). PMID: 40006600
: Chemoresistance of breast cancers (BCs) is a major impediment to current chemotherapeutics that urges the development of new drugs and new therapeutic approaches. To that end, phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs)...
2.
N-Phenyl ureidobenzenesulfonates, a novel class of human dihydroorotate dehydrogenase inhibitors inducing differentiation and apoptosis in acute myeloid leukemia cells
Bouzriba C, Chavez Alvarez A, Ouellette V, Gagne-Boulet M, Hamel-Cote G, Bastien D, et al.
Biomed Pharmacother . 2024 Dec; 181:117717. PMID: 39637752
N-Phenyl ureidobenzensulfonates (PUB-SOs) are a novel family of dihydroorotate dehydrogenase (DHODH) inhibitors. Herein, we investigate the potential of PUB-SOs to induce acute myeloid leukemia (AML) cell differentiation and apoptosis. To...
3.
Pyridinyl 4-(2-oxoalkylimidazolidin-1-yl)benzenesulfonates and their hydrochloride salts as novel water soluble antimitotic prodrugs bioactivated by cytochrome P450 1A1 in breast cancer cells
Ouellette V, Bouzriba C, Chavez Alvarez A, Bruxelles Q, Hamel-Cote G, Fortin S
RSC Med Chem . 2024 Sep; PMID: 39281801
We developed first-in-class antimitotic prodrugs phenyl 4-(2-oxo-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs) bioactivated by cytochrome P450 (CYP) 1A1 that are highly selective toward several breast cancer cells. However, they show sparingly water solubility. Therefore,...
4.
Modification of the phenyl ring B of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates by pyridinyl moiety leads to novel antimitotics targeting the colchicine-binding site
Ouellette V, Bouzriba C, Chavez Alvarez A, Hamel-Cote G, Fortin S
Bioorg Med Chem Lett . 2024 Apr; 105:129745. PMID: 38614151
A series of 8 novel pyridinyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PYRIB-SOs) were designed, prepared and evaluated for their mechanism of action. PYRIB-SOs were found to have antiproliferative activity in the nanomolar to submicromolar...
5.
Design, synthesis and biological evaluation of new 2,6-difluorinated phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates as new antimicrotubule agents
Bouzriba C, Gagne-Boulet M, Chavez Alvarez A, Ouellette V, Laverdiere I, Fortin S
Bioorg Chem . 2024 Mar; 146:107299. PMID: 38547722
We previously discovered a novel family of antimicrotubule agents designated as phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates (PIB-SOs). In this study, we evaluated the effect of the difluorination of the aromatic ring bearing the...
6.
4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamide salts: Novel hydrosoluble prodrugs of antimitotics selectively bioactivated by the cytochrome P450 1A1 in breast cancer cells
Ouellette V, Chavez Alvarez A, Bouzriba C, Hamel-Cote G, Fortin S
Bioorg Chem . 2023 Sep; 140:106820. PMID: 37672952
4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides (PAIB-SAs) are members of a new family of prodrugs bioactivated by cytochrome P450 1A1 (CYP1A1) in breast cancer cells into their potent 4-(2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamide metabolites (PIB-SAs). One of the predominant...
7.
Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes
Chavez Alvarez A, Bouzriba C, Moreau E, Auzeloux P, Besse S, Ouellette V, et al.
J Med Chem . 2023 Feb; 66(4):2477-2497. PMID: 36780426
Phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs) are a new family of antimitotic prodrugs bioactivated in breast cancer cells expressing CYP1A1. In this study, we report that the C-labeled prototypical PAIB-SO [C]CEU-818 and its...
8.
Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation
Bouzriba C, Chavez Alvarez A, Gagne-Boulet M, Ouellette V, Lacroix J, Cote M, et al.
Eur J Med Chem . 2021 Nov; 229:114003. PMID: 34839998
We recently discovered a new family of prodrugs deriving from phenyl 4-(2-oxo-3-imidazolidin-1-yl)benzenesulfonates (PIB-SOs) bioactivatable by cytochrome P450 1A1 (CYP1A1) into potent antimitotics referred to as phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates (PAIB-SOs). PAIB-SOs display...
9.
Second-generation testosterone-platinum(II) hybrids for site-specific treatment of androgen receptor positive prostate cancer: Design, synthesis and antiproliferative activity
Ouellette V, Cote M, Gaudreault R, Tajmir-Riahi H, Berube G
Eur J Med Chem . 2019 Jul; 179:660-666. PMID: 31279298
Prostate cancer is the most diagnosed type of cancer in men in Canada. One out of eight men will be stricken with this disease during the course of his life....
10.
Cloning and characterization of norbelladine synthase catalyzing the first committed reaction in Amaryllidaceae alkaloid biosynthesis
Singh A, Massicotte M, Garand A, Tousignant L, Ouellette V, Berube G, et al.
BMC Plant Biol . 2018 Dec; 18(1):338. PMID: 30526483
Background: Amaryllidaceae alkaloids (AAs) are a large group of plant-specialized metabolites displaying an array of biological and pharmacological properties. Previous investigations on AA biosynthesis have revealed that all AAs share...