Ville Tahtinen
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Explore the profile of Ville Tahtinen including associated specialties, affiliations and a list of published articles.
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10
Citations
39
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Recent Articles
1.
Laine T, Deshpande P, Tahtinen V, Coffey E, Virta P
Chembiochem
. 2024 Nov;
26(6):e202400908.
PMID: 39544138
Molecular Spherical Nucleic Acids (MSNAs) are atomically uniform dendritic nanostructures and potential delivery vehicles for oligonucleotides. The radial formulation combined with covalent conjugation may hide the oligonucleotide content and simultaneously...
2.
Gulumkar V, Tahtinen V, Ali A, Rahkila J, Valle-Delgado J, Aarela A, et al.
ACS Omega
. 2022 Jan;
7(1):1329-1336.
PMID: 35036794
Bingel cyclopropanation between Buckminster fullerene and a heteroarmed malonate was utilized to produce a hexakis-functionalized C core, with azide and tetrazine units. This orthogonally bifunctional C scaffold can be selectively...
3.
Tahtinen V, Gulumkar V, Maity S, Yliperttula A, Siekkinen S, Laine T, et al.
Bioconjug Chem
. 2022 Jan;
33(1):206-218.
PMID: 34985282
Glyco-decorated spherical nucleic acids (SNAs) may be attractive delivery vehicles, emphasizing the sugar-specific effect on the outer sphere of the construct and at the same time hiding unfavorable distribution properties...
4.
Gulumkar V, Aarela A, Moisio O, Rahkila J, Tahtinen V, Leimu L, et al.
Bioconjug Chem
. 2021 May;
32(6):1130-1138.
PMID: 33998229
An azide-functionalized 12-armed Buckminster fullerene has been monosubstituted in organic media with a substoichiometric amount of cyclooctyne-modified oligonucleotides. Exposing the intermediate products then to the same reaction (i.e., strain-promoted alkyne-azide...
5.
Osterlund T, Aho A, Aarela A, Tahtinen V, Korhonen H, Virta P
Curr Protoc Nucleic Acid Chem
. 2020 Dec;
83(1):e122.
PMID: 33290641
A detailed protocol for preparation 3'-glycoconjugated oligonucleotides is described based on one-pot immobilization of 4,4'-dimethoxytrityl-protected carbohydrates to a solid support followed by on-support peracetylation and automated oligonucleotide assembly. Compared to...
6.
Tahtinen V, Verhassel A, Tuomela J, Virta P
Chembiochem
. 2019 Jun;
20(24):3041-3051.
PMID: 31206960
γ-Modified (i.e., (S)-aminomethyl, (S)-acetamidomethyl, (R)-4-(hydroxymethyl)triazol-1-ylmethyl, and (S)-guanidinylmethyl) triplex-forming peptide nucleic acids (TFPNAs) were synthesized and the effect of the backbone modifications on the binding to a miR-215 model was studied....
7.
Granqvist L, Tahtinen V, Virta P
Molecules
. 2019 Feb;
24(3).
PMID: 30736311
Glycosidic (β-1''→6, 3' and 4') site isomers of neomycin B (i.e., neobiosamine (β-1''→6, 3' and 4') neamines) have been synthesized in a straightforward manner. Peracetylated neomycin azide was used as...
8.
Granqvist L, Kraszewski A, Tahtinen V, Virta P
Molecules
. 2017 May;
22(5).
PMID: 28481305
Phosphoramidite building blocks of ribostamycin ( and ), that may be incorporated at any position of the oligonucleotide sequence, were synthesized. The building blocks, together with a previously described neomycin-modified...
9.
Tahtinen V, Granqvist L, Murtola M, Stromberg R, Virta P
Chemistry
. 2017 Apr;
23(29):7113-7124.
PMID: 28370485
Triplex-forming peptide nucleic acids (TFPNAs) were targeted to double-helical regions of F-labeled RNA hairpin models (a UA-rich duplex with a hexaethylene glycol (heg) loop and a microRNA model, miR-215). In...
10.
Tahtinen V, Granqvist L, Virta P
Bioorg Med Chem
. 2015 Jun;
23(15):4472-4480.
PMID: 26118338
Neomycin-conjugated homopyrimidine oligo 2'-deoxyribonucleotides have been synthesized on a solid phase and their potential as triplex forming oligonucleotides (TFOs) with DNA-duplexes has been studied. For the synthesis of the conjugates,...