Ville Hietakangas
Overview
Explore the profile of Ville Hietakangas including associated specialties, affiliations and a list of published articles.
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Articles
53
Citations
2022
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Recent Articles
1.
Cadena Del Castillo C, Deniz O, van Geest F, Rosseels L, Stockmans I, Robciuc M, et al.
Sci Adv
. 2025 Mar;
11(11):eadt4548.
PMID: 40073115
Carbohydrate-responsive element binding protein (ChREBP) and Max-like protein X (MLX) form a heterodimeric transcription factor complex that couples intracellular sugar levels to carbohydrate and lipid metabolism. To promote the expression...
2.
Cadena Del Castillo C, Deniz O, van Geest F, Rosseels L, Stockmans I, Robciuc M, et al.
bioRxiv
. 2024 Sep;
PMID: 39282306
The heterodimeric ChREBP-MLX transcription factor complex is a key mediator that couples intracellular sugar levels to carbohydrate and lipid metabolism. To promote the expression of target genes, two ChREBP-MLX heterodimers...
3.
Jalil S, Keskinen T, Juutila J, Sartori Maldonado R, Euro L, Suomalainen A, et al.
Am J Hum Genet
. 2024 Apr;
111(4):714-728.
PMID: 38579669
Argininosuccinate lyase deficiency (ASLD) is a recessive metabolic disorder caused by variants in ASL. In an essential step in urea synthesis, ASL breaks down argininosuccinate (ASA), a pathognomonic ASLD biomarker....
4.
Mattila J, Viitanen A, Fabris G, Strutynska T, Korzelius J, Hietakangas V
Sci Adv
. 2024 Feb;
10(6):eadi2671.
PMID: 38335286
The adult intestine is a regionalized organ, whose size and cellular composition are adjusted in response to nutrient status. This involves dynamic regulation of intestinal stem cell (ISC) proliferation and...
5.
Paukstyte J, Lopez Cabezas R, Feng Y, Tong K, Schnyder D, Elomaa E, et al.
Mol Cell
. 2023 Sep;
83(18):3360-3376.e11.
PMID: 37699397
Aging is associated with progressive phenotypic changes. Virtually all cellular phenotypes are produced by proteins, and their structural alterations can lead to age-related diseases. However, we still lack comprehensive knowledge...
6.
Barsby T, Vahakangas E, Ustinov J, Montaser H, Ibrahim H, Lithovius V, et al.
Cell Rep
. 2023 Aug;
42(8):112970.
PMID: 37556323
Pancreatic islets regulate blood glucose homeostasis through the controlled release of insulin; however, current metabolic models of glucose-sensitive insulin secretion are incomplete. A comprehensive understanding of islet metabolism is integral...
7.
Ronkko J, Rodriguez Y, Rasila T, Torregrosa-Munumer R, Pennonen J, Kvist J, et al.
Cell Calcium
. 2023 Jul;
114:102782.
PMID: 37481871
Inositol 1,4,5-trisphosphate receptors (IPRs) are ER Ca-release channels that control a broad set of cellular processes. Animal models lacking IPRs in different combinations display severe developmental phenotypes. Given the importance...
8.
van den Berg L, Kokki K, Wowro S, Petricek K, Deniz O, Stegmann C, et al.
Cell Rep
. 2023 Jul;
42(7):112739.
PMID: 37405919
The ability to feed on a sugar-containing diet depends on a gene regulatory network controlled by the intracellular sugar sensor Mondo/ChREBP-Mlx, which remains insufficiently characterized. Here, we present a genome-wide...
9.
Deniz O, Hasygar K, Hietakangas V
FEBS Lett
. 2022 Oct;
597(5):601-607.
PMID: 36266944
Extracellular signal-regulated kinase 7 (ERK7), also known as ERK8 and MAPK15, is an atypical member of the MAP kinase family. Compared with other MAP kinases, the biological roles of ERK7...
10.
Viitanen A, Gullmets J, Morikka J, Katajisto P, Mattila J, Hietakangas V
Cell Rep Methods
. 2022 Apr;
1(5):100059.
PMID: 35474669
The intestine is divided into functionally distinct regions along the anteroposterior (A/P) axis. How the regional identity influences the function of intestinal stem cells (ISCs) and their offspring remain largely...