Vijayalakshmi Mahadevan
Overview
Explore the profile of Vijayalakshmi Mahadevan including associated specialties, affiliations and a list of published articles.
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19
Citations
330
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Recent Articles
1.
Sharma S, Rani H, Mahesh Y, Jolly M, Dixit J, Mahadevan V
Transl Oncol
. 2024 Feb;
43:101848.
PMID: 38412660
Epithelial to Mesenchymal transition (EMT) drives cancer metastasis and is governed by genetic and epigenetic alterations at multiple levels of regulation. It is well established that loss/mutation of p53 confers...
2.
Yang H, Huebner K, Hampel C, Erlenbach-Wuensch K, Selvamani S, Shukla V, et al.
BMC Cancer
. 2023 May;
23(1):480.
PMID: 37237279
Background: The role of ATF2 in colon cancer (CC) is controversial. Recently, we reported that low ATF2 expression is characteristic of highly invasive tumors, suggesting that ATF2 might also be...
3.
ATF2 loss promotes tumor invasion in colorectal cancer cells via upregulation of cancer driver TROP2
Huebner K, Erlenbach-Wuensch K, Prochazka J, Sheraj I, Hampel C, Mrazkova B, et al.
Cell Mol Life Sci
. 2022 Jul;
79(8):423.
PMID: 35838828
In cancer, the activating transcription factor 2 (ATF2) has pleiotropic functions in cellular responses to growth stimuli, damage, or inflammation. Due to only limited studies, the significance of ATF2 in...
4.
Lindner P, Paul S, Eckstein M, Hampel C, Muenzner J, Erlenbach-Wuensch K, et al.
Cell Death Dis
. 2020 Feb;
11(2):147.
PMID: 32094334
Epigenetic deregulation remarkably triggers mechanisms associated with tumor aggressiveness like epithelial-mesenchymal transition (EMT). Since EMT is a highly complex, but also reversible event, epigenetic processes such as DNA methylation or...
5.
Huebner K, Prochazka J, Monteiro A, Mahadevan V, Schneider-Stock R
Mutagenesis
. 2019 Dec;
34(5-6):375-389.
PMID: 31799611
In contrast to the continuous increase in survival rates for many cancer entities, colorectal cancer (CRC) and pancreatic cancer are predicted to be ranked among the top 3 cancer-related deaths...
6.
Maiuthed A, Ninsontia C, Erlenbach-Wuensch K, Ndreshkjana B, Muenzner J, Caliskan A, et al.
Cancers (Basel)
. 2018 Oct;
10(10).
PMID: 30304835
The oncogenic cytoplasmic p21 contributes to cancer aggressiveness and chemotherapeutic failure. However, the molecular mechanisms remain obscure. Here, we show for the first time that cytoplasmic p21 mediates 5-Fluorouracil (5FU)...
7.
Hariprakash J, Vellarikkal S, Verma A, Ranawat A, Jayarajan R, Ravi R, et al.
Database (Oxford)
. 2018 Sep;
2018:1-10.
PMID: 30184194
South Asia is home to $\sim $20% of the world population and characterized by distinct ethnic, linguistic, cultural and genetic lineages. Only limited representative samples from the region have found...
8.
Ramadoss M, Mahadevan V
Drug Discov Today
. 2017 Sep;
23(1):76-89.
PMID: 28943305
Epigenetic and genomic alterations regulate the transcriptional landscape of cells during cancer onset and progression. Recent clinical studies targeting the epigenetic 'readers' (bromodomains) for cancer therapy have established the effectiveness...
9.
R M, Ahmed P H, Mahadevan V
J Biomol Struct Dyn
. 2017 Mar;
36(4):938-955.
PMID: 28264628
Besides inactivating tumour suppressor activity in cells, mutations in p53 confer significant oncogenic functions and promote metastasis and resistance to anticancer therapy. A variety of therapies involving genetic and epigenetic...
10.
Kristam R, Rao S, DCruz A, Mahadevan V, Viswanadhan V
J Mol Graph Model
. 2017 Jan;
72:112-128.
PMID: 28092830
Transient Receptor Potential Vanilloid, member 1 (TRPV1), is a non-selective cation channel belonging to the transient receptor potential (TRP) family of ion channels. It occurs in the peripheral and central...