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Victor Osoti

Explore the profile of Victor Osoti including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 25
Citations 396
Followers 0
Related Specialties
Tropical Medicine
Biomedical Engineering
General Medicine
Top 10 Co-Authors
Philip Bejon
Lynette Isabella Ochola-Oyier
Leonard Ndwiga
Kevin Wamae
Teun Bousema
Patrick Sawa
Kelvin M Kimenyi
Chris Drakeley
George Omweri
Jonathan Cox
Published In
Malar J
Wellcome Open Res
J Infect Dis
Antimicrob Agents Chemother
BMC Med
Affiliations
Soon will be listed here.
Recent Articles
1.
Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya
Osoti V, Wamae K, Ndwiga L, Gichuki P, Okoyo C, Kepha S, et al.
BMC Infect Dis . 2025 Jan; 25(1):73. PMID: 39819451
Background: To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. Recent advances in next-generation sequencing (NGS)...
2.
ONT sequencing identifies a high prevalence of sensitive, triple mutant and single mutant parasites within an ANC population in Nigeria
Adegbola A, Ndwiga L, Wamae K, Osoti V, Bolaji O, Bejon P, et al.
Front Genet . 2024 Nov; 15:1470156. PMID: 39483850
Background: Malaria in pregnancy is a major public health issue, particularly among vulnerable populations in malaria-endemic sub-Saharan African countries. To mitigate its risks, WHO recommends sulphadoxine-pyrimethamine (SP) for chemoprevention and...
3.
A cross-sectional analysis identifies a low prevalence of  species infections in symptomatic and asymptomatic individuals in Kilifi county, Kenya
Akinyi M, Chifwete M, Ndwiga L, Kimenyi K, Osoti V, Ochola-Oyier L
Wellcome Open Res . 2024 Oct; 7:207. PMID: 39364258
Background: The focus on diagnosis has led to an underestimation of the global burden of malaria resulting from neglected species. However, there is still scarce data on the prevalence of...
4.
A retrospective analysis of drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda
Ogwang R, Osoti V, Wamae K, Ndwiga L, Muteru K, Ningwa A, et al.
Antimicrob Agents Chemother . 2024 Aug; 68(9):e0157623. PMID: 39136465
The emergence of drug-resistant parasites in sub-Saharan Africa will substantially challenge malaria control. Here, we evaluated the frequency of common drug resistance markers among adolescents from Northern Uganda with asymptomatic...
5.
Low frequency of deletions from symptomatic infections at a primary healthcare facility in Kilifi, Kenya
Okanda D, Ndwiga L, Osoti V, Achieng N, Wambua J, Ngetsa C, et al.
Front Epidemiol . 2024 Mar; 3:1083114. PMID: 38455911
There is a growing concern for malaria control in the Horn of Africa region due to the spread and rise in the frequency of Histidine-rich Protein (hrp) 2 and 3...
6.
Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host diversity throughout treatment in a clinical drug trial
Wamae K, Ndwiga L, Kharabora O, Kimenyi K, Osoti V, de Laurent Z, et al.
Wellcome Open Res . 2023 Jul; 7:95. PMID: 37456906
Introduction: Antimalarial therapeutic efficacy studies are routinely conducted in malaria-endemic countries to assess the effectiveness of antimalarial treatment strategies. Targeted amplicon sequencing (AmpSeq) uniquely identifies and quantifies genetically distinct parasites...
7.
Validation of saline, PBS and a locally produced VTM at varying storage conditions to detect the SARS-CoV-2 virus by qRT-PCR
Ngetsa C, Osoti V, Okanda D, Marura F, Shah K, Karanja H, et al.
PLoS One . 2023 Feb; 18(2):e0280685. PMID: 36780469
Coronavirus Disease-2019 tests require a Nasopharyngeal (NP) and/or Oropharyngeal (OP) specimen from the upper airway, from which virus RNA is extracted and detected through quantitative reverse transcription-Polymerase Chain Reaction (qRT-PCR)....
8.
Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018
Kimenyi K, Wamae K, Ngoi J, de Laurent Z, Ndwiga L, Osoti V, et al.
Malar J . 2022 Jun; 21(1):192. PMID: 35725456
Background: High levels of genetic diversity are common characteristics of Plasmodium falciparum parasite populations in high malaria transmission regions. There has been a decline in malaria transmission intensity over 12...
9.
Amplicon Sequencing as a Potential Surveillance Tool for Complexity of Infection and Drug Resistance Markers in Plasmodium falciparum Asymptomatic Infections
Wamae K, Kimenyi K, Osoti V, de Laurent Z, Ndwiga L, Kharabora O, et al.
J Infect Dis . 2022 Apr; 226(5):920-927. PMID: 35429395
Background: Genotyping Plasmodium falciparum subpopulations in malaria infections is an important aspect of malaria molecular epidemiology to understand within-host diversity and the frequency of drug resistance markers. Methods: We characterized...
10.
An optimization of four SARS-CoV-2 qRT-PCR assays in a Kenyan laboratory to support the national COVID-19 rapid response teams
Mohammed K, de Laurent Z, Omuoyo D, Lewa C, Gicheru E, Cheruiyot R, et al.
Wellcome Open Res . 2022 Mar; 5:162. PMID: 35330938
 The COVID-19 pandemic relies on real-time polymerase chain reaction (qRT-PCR) for the detection of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), to facilitate roll-out of patient care and infection control...