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Kevin Wamae

Explore the profile of Kevin Wamae including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 16
Citations 150
Followers 0
Related Specialties
Pharmacology
Biomedical Engineering
Infectious Diseases
Top 10 Co-Authors
Lynette Isabella Ochola-Oyier
Philip Bejon
Leonard Ndwiga
Victor Osoti
Kelvin M Kimenyi
Jeffrey A Bailey
Ashenafi Assefa
Robert W Snow
Jonathan J Juliano
Jonathan B Parr
Published In
Wellcome Open Res
Antimicrob Agents Chemother
Malar J
J Infect Dis
Front Immunol
Affiliations
Soon will be listed here.
Recent Articles
1.
Application of a new highly multiplexed amplicon sequencing tool to evaluate antimalarial resistance and relatedness in individual and pooled samples from Dschang, Cameroon
Sadler J, Simkin A, Tchuenkam V, Gerdes Gyuricza I, Fola A, Wamae K, et al.
Front Parasitol . 2025 Feb; 3:1509261. PMID: 39975479
Background: Resistance to antimalarial drugs remains a major obstacle to malaria elimination. Multiplexed, targeted amplicon sequencing is being adopted for surveilling resistance and dissecting the genetics of complex malaria infections....
2.
Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya
Osoti V, Wamae K, Ndwiga L, Gichuki P, Okoyo C, Kepha S, et al.
BMC Infect Dis . 2025 Jan; 25(1):73. PMID: 39819451
Background: To understand the emergence and spread of drug-resistant parasites in malaria-endemic areas, accurate assessment and monitoring of antimalarial drug resistance markers is critical. Recent advances in next-generation sequencing (NGS)...
3.
ONT sequencing identifies a high prevalence of sensitive, triple mutant and single mutant parasites within an ANC population in Nigeria
Adegbola A, Ndwiga L, Wamae K, Osoti V, Bolaji O, Bejon P, et al.
Front Genet . 2024 Nov; 15:1470156. PMID: 39483850
Background: Malaria in pregnancy is a major public health issue, particularly among vulnerable populations in malaria-endemic sub-Saharan African countries. To mitigate its risks, WHO recommends sulphadoxine-pyrimethamine (SP) for chemoprevention and...
4.
Application of a new highly multiplexed amplicon sequencing tool to evaluate antimalarial resistance and relatedness in individual and pooled samples from Dschang, Cameroon
Sadler J, Simkin A, Tchuenkam V, Gerdes Gyuricza I, Fola A, Wamae K, et al.
medRxiv . 2024 Oct; PMID: 39417120
Background: Resistance to antimalarial drugs remains a major obstacle to malaria elimination. Multiplexed, targeted amplicon sequencing is being adopted for surveilling resistance and dissecting the genetics of complex malaria infections....
5.
A retrospective analysis of drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda
Ogwang R, Osoti V, Wamae K, Ndwiga L, Muteru K, Ningwa A, et al.
Antimicrob Agents Chemother . 2024 Aug; 68(9):e0157623. PMID: 39136465
The emergence of drug-resistant parasites in sub-Saharan Africa will substantially challenge malaria control. Here, we evaluated the frequency of common drug resistance markers among adolescents from Northern Uganda with asymptomatic...
6.
Detection of P. malariae using a new rapid isothermal amplification lateral flow assay
Assefa A, Wamae K, Hennelly C, Ngasala B, Muller M, Kalonji A, et al.
Malar J . 2024 Apr; 23(1):104. PMID: 38609964
Background: While Plasmodium falciparum and Plasmodium vivax cause the majority of malaria cases and deaths, infection by Plasmodium malariae and other Plasmodium species also causes morbidity and mortality. Current understanding...
7.
Targeted amplicon deep sequencing of ama1 and mdr1 to track within-host diversity throughout treatment in a clinical drug trial
Wamae K, Ndwiga L, Kharabora O, Kimenyi K, Osoti V, de Laurent Z, et al.
Wellcome Open Res . 2023 Jul; 7:95. PMID: 37456906
Introduction: Antimalarial therapeutic efficacy studies are routinely conducted in malaria-endemic countries to assess the effectiveness of antimalarial treatment strategies. Targeted amplicon sequencing (AmpSeq) uniquely identifies and quantifies genetically distinct parasites...
8.
Maintenance of high temporal Plasmodium falciparum genetic diversity and complexity of infection in asymptomatic and symptomatic infections in Kilifi, Kenya from 2007 to 2018
Kimenyi K, Wamae K, Ngoi J, de Laurent Z, Ndwiga L, Osoti V, et al.
Malar J . 2022 Jun; 21(1):192. PMID: 35725456
Background: High levels of genetic diversity are common characteristics of Plasmodium falciparum parasite populations in high malaria transmission regions. There has been a decline in malaria transmission intensity over 12...
9.
Epidemiology of COVID-19 infections on routine polymerase chain reaction (PCR) and serology testing in Coastal Kenya
Nyagwange J, Ndwiga L, Muteru K, Wamae K, Tuju J, Testing Team C, et al.
Wellcome Open Res . 2022 May; 7:69. PMID: 35505772
There are limited studies in Africa describing the epidemiology, clinical characteristics and serostatus of individuals tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We tested routine samples from...
10.
Amplicon Sequencing as a Potential Surveillance Tool for Complexity of Infection and Drug Resistance Markers in Plasmodium falciparum Asymptomatic Infections
Wamae K, Kimenyi K, Osoti V, de Laurent Z, Ndwiga L, Kharabora O, et al.
J Infect Dis . 2022 Apr; 226(5):920-927. PMID: 35429395
Background: Genotyping Plasmodium falciparum subpopulations in malaria infections is an important aspect of malaria molecular epidemiology to understand within-host diversity and the frequency of drug resistance markers. Methods: We characterized...