Victor Kotelianski
Overview
Explore the profile of Victor Kotelianski including associated specialties, affiliations and a list of published articles.
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10
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1042
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Recent Articles
1.
Dahlman J, Barnes C, Khan O, Thiriot A, Jhunjunwala S, Shaw T, et al.
Nat Nanotechnol
. 2014 May;
9(8):648-655.
PMID: 24813696
Dysfunctional endothelium contributes to more diseases than any other tissue in the body. Small interfering RNAs (siRNAs) can help in the study and treatment of endothelial cells in vivo by...
2.
FitzGerald K, Frank-Kamenetsky M, Shulga-Morskaya S, Liebow A, Bettencourt B, Sutherland J, et al.
Lancet
. 2013 Oct;
383(9911):60-68.
PMID: 24094767
Background: Proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to LDL receptors, leading to their degradation. Genetics studies have shown that loss-of-function mutations in PCSK9 result in reduced plasma LDL cholesterol...
3.
Chen P, Qin L, Barnes C, Charisse K, Yi T, Zhang X, et al.
Cell Rep
. 2012 Dec;
2(6):1684-96.
PMID: 23200853
Maintenance of normal endothelial function is critical to various aspects of blood vessel function, but its regulation is poorly understood. In this study, we show that disruption of baseline fibroblast...
4.
Nakayama T, Butler J, Sehgal A, Severgnini M, Racie T, Sharman J, et al.
Mol Ther
. 2012 Aug;
20(8):1582-9.
PMID: 22850721
Therapeutics based on RNA interference (RNAi) have emerged as a potential new class of drugs for treating human disease by silencing the target messenger RNA (mRNA), thereby reducing levels of...
5.
Fukuda D, Aikawa E, Swirski F, Novobrantseva T, Kotelianski V, Gorgun C, et al.
Proc Natl Acad Sci U S A
. 2012 Jun;
109(27):E1868-77.
PMID: 22699504
Atherosclerosis and insulin resistance are major components of the cardiometabolic syndrome, a global health threat associated with a systemic inflammatory state. Notch signaling regulates tissue development and participates in innate...
6.
Chen Q, Butler D, Querbes W, Pandey R, Ge P, Maier M, et al.
J Control Release
. 2010 Feb;
144(2):227-32.
PMID: 20170694
Conjugation of small interfering RNA (siRNA) with lipophilic molecules has been demonstrated to enhance cellular uptake in cell culture and to produce efficient endogenous gene silencing in the liver after...
7.
Alvarez R, Elbashir S, Borland T, Toudjarska I, Hadwiger P, John M, et al.
Antimicrob Agents Chemother
. 2009 Jun;
53(9):3952-62.
PMID: 19506055
We describe the design and characterization of a potent human respiratory syncytial virus (RSV) nucleocapsid gene-specific small interfering RNA (siRNA), ALN-RSV01. In in vitro RSV plaque assays, ALN-RSV01 showed a...
8.
Querbes W, Ge P, Zhang W, Fan Y, Costigan J, Charisse K, et al.
Oligonucleotides
. 2008 Dec;
19(1):23-29.
PMID: 19093781
The most significant challenge remaining in the development of small interfering RNAs (siRNAs) as a new class of therapeutic drugs is successful delivery in vivo. The majority of reported studies...
9.
Conrad C, Boyman O, Tonel G, Tun-Kyi A, Laggner U, De Fougerolles A, et al.
Nat Med
. 2007 Jul;
13(7):836-42.
PMID: 17603494
Psoriasis is a common T cell-mediated autoimmune inflammatory disease. We show that blocking the interaction of alpha1beta1 integrin (VLA-1) with collagen prevented accumulation of epidermal T cells and immunopathology of...
10.
Richter M, Ray S, Chapman T, Austin S, Rebhahn J, Mosmann T, et al.
J Immunol
. 2007 Mar;
178(7):4506-16.
PMID: 17372009
Most viral infections occur in extralymphoid tissues, yet the mechanisms that regulate lymphocytes in these environments are poorly understood. One feature common to many extralymphoid environments is an abundance of...