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Venugopalan D Nair

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Articles 46
Citations 1020
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Recent Articles
1.
Comendul A, Ruf-Zamojski F, Ford C, Agarwal P, Zaslavsky E, Nudelman G, et al.
STAR Protoc . 2025 Jan; 6(1):103607. PMID: 39869481
Host response to environmental exposures such as pathogens and chemicals can include modifications to the epigenome and transcriptome. Improved signature discovery, including the identification of the agent and timing of...
2.
Schuetter J, Minard-Smith A, Hill B, Beare J, Vornholt A, Burke T, et al.
Epigenomics . 2024 Sep; 16(14):1013-1029. PMID: 39225561
The epigenome influences gene regulation and phenotypes in response to exposures. Epigenome assessment can determine exposure history aiding in diagnosis. Here we developed and implemented a machine learning algorithm, the...
3.
Nair V, Pincas H, Smith G, Zaslavsky E, Ge Y, Amper M, et al.
Cell Genom . 2024 May; 4(6):100421. PMID: 38697122
Regular exercise has many physical and brain health benefits, yet the molecular mechanisms mediating exercise effects across tissues remain poorly understood. Here we analyzed 400 high-quality DNA methylation, ATAC-seq, and...
4.
Nair V, Pincas H, Amper M, Ge Y, Vasoya M, Raja A, et al.
STAR Protoc . 2024 May; 5(2):103007. PMID: 38691461
Although reduced representation bisulfite sequencing (RRBS) measures DNA methylation (DNAme) across CpG-rich genomic regions with high sensitivity, the assay can be time-consuming and prone to batch effects. Here, we present...
5.
Jakicic J, Kohrt W, Houmard J, Miller M, Radom-Aizik S, Rasmussen B, et al.
J Appl Physiol (1985) . 2024 Apr; 137(3):473-493. PMID: 38634503
Physical activity, including structured exercise, is associated with favorable health-related chronic disease outcomes. Although there is evidence of various molecular pathways that affect these responses, a comprehensive molecular map of...
6.
Chen X, Wang Y, Cappuccio A, Cheng W, Zamojski F, Nair V, et al.
Nat Comput Sci . 2024 Jan; 3(9):805. PMID: 38177788
No abstract available.
7.
Chen X, Wang Y, Cappuccio A, Cheng W, Zamojski F, Nair V, et al.
Nat Comput Sci . 2023 Nov; 3(7):644-657. PMID: 37974651
Resolving chromatin-remodeling-linked gene expression changes at cell-type resolution is important for understanding disease states. Here we describe MAGICAL (Multiome Accessibility Gene Integration Calling and Looping), a hierarchical Bayesian approach that...
8.
Rubenstein A, Smith G, Zhang Z, Chen X, Chambers T, Ruf-Zamojski F, et al.
bioRxiv . 2023 Oct; PMID: 37808658
Endurance exercise is an important health modifier. We studied cell-type specific adaptations of human skeletal muscle to acute endurance exercise using single-nucleus (sn) multiome sequencing in human vastus lateralis samples...
9.
Alonso C, David C, Toufaily C, Wang Y, Zhou X, Ongaro L, et al.
Endocrinology . 2023 Mar; 164(5). PMID: 36951304
Follicle-stimulating hormone (FSH), a dimeric glycoprotein produced by pituitary gonadotrope cells, regulates spermatogenesis in males and ovarian follicle growth in females. Hypothalamic gonadotropin-releasing hormone (GnRH) stimulates FSHβ subunit gene (Fshb)...
10.
Zhang Z, Sauerwald N, Cappuccio A, Ramos I, Nair V, Nudelman G, et al.
Cell Rep Methods . 2023 Mar; 3(2):100395. PMID: 36936082
Assays detecting blood transcriptome changes are studied for infectious disease diagnosis. Blood-based RNA alternative splicing (AS) events, which have not been well characterized in pathogen infection, have potential normalization and...