Venky N Iyer
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Explore the profile of Venky N Iyer including associated specialties, affiliations and a list of published articles.
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8
Citations
1999
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Recent Articles
1.
Peterson B, Hare E, Iyer V, Storage S, Conner L, Papaj D, et al.
PLoS One
. 2009 Mar;
4(3):e4688.
PMID: 19259274
The identification of regulatory sequences in animal genomes remains a significant challenge. Comparative genomic methods that use patterns of evolutionary conservation to identify non-coding sequences with regulatory function have yielded...
2.
Hare E, Peterson B, Iyer V, Meier R, Eisen M
PLoS Genet
. 2008 Jun;
4(6):e1000106.
PMID: 18584029
The gene expression pattern specified by an animal regulatory sequence is generally viewed as arising from the particular arrangement of transcription factor binding sites it contains. However, we demonstrate here...
3.
Li X, MacArthur S, Bourgon R, Nix D, Pollard D, Iyer V, et al.
PLoS Biol
. 2008 Feb;
6(2):e27.
PMID: 18271625
Identifying the genomic regions bound by sequence-specific regulatory factors is central both to deciphering the complex DNA cis-regulatory code that controls transcription in metazoans and to determining the range of...
4.
Clark A, Eisen M, Smith D, Bergman C, Oliver B, Markow T, et al.
Nature
. 2007 Nov;
450(7167):203-18.
PMID: 17994087
Comparative analysis of multiple genomes in a phylogenetic framework dramatically improves the precision and sensitivity of evolutionary inference, producing more robust results than single-genome analyses can provide. The genomes of...
5.
Pollard D, Iyer V, Moses A, Eisen M
PLoS Genet
. 2006 Nov;
2(10):e173.
PMID: 17132051
The phylogenetic relationship of the now fully sequenced species Drosophila erecta and D. yakuba with respect to the D. melanogaster species complex has been a subject of controversy. All three...
6.
Moses A, Pollard D, Nix D, Iyer V, Li X, Biggin M, et al.
PLoS Comput Biol
. 2006 Oct;
2(10):e130.
PMID: 17040121
The gain and loss of functional transcription factor binding sites has been proposed as a major source of evolutionary change in cis-regulatory DNA and gene expression. We have developed an...
7.
Pollard D, Moses A, Iyer V, Eisen M
BMC Bioinformatics
. 2006 Aug;
7:376.
PMID: 16904011
Background: Molecular evolutionary studies of noncoding sequences rely on multiple alignments. Yet how multiple alignment accuracy varies across sequence types, tree topologies, divergences and tools, and further how this variation...
8.
Moses A, Chiang D, Pollard D, Iyer V, Eisen M
Genome Biol
. 2004 Dec;
5(12):R98.
PMID: 15575972
We introduce a method (MONKEY) to identify conserved transcription-factor binding sites in multispecies alignments. MONKEY employs probabilistic models of factor specificity and binding-site evolution, on which basis we compute the...