Vardit Kram
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Explore the profile of Vardit Kram including associated specialties, affiliations and a list of published articles.
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21
Citations
723
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Recent Articles
1.
de Castro L, Whitlock J, Michel Z, Pan K, Taylor J, Szymczuk V, et al.
Bone Res
. 2024 Feb;
12(1):10.
PMID: 38378678
Fibrous dysplasia (FD) is a rare, disabling skeletal disease for which there are no established treatments. Growing evidence supports inhibiting the osteoclastogenic factor receptor activator of nuclear kappa-B ligand (RANKL)...
2.
Shainer R, Kram V, Kilts T, Li L, Doyle A, Shainer I, et al.
Front Physiol
. 2023 Mar;
14:1119368.
PMID: 36875017
Endochondral bone development and regeneration relies on activation and proliferation of periosteum derived-cells (PDCs). Biglycan (Bgn), a small proteoglycan found in extracellular matrix, is known to be expressed in bone...
3.
Komori T, Ji Y, Pham H, Jani P, Kilts T, Kram V, et al.
JBMR Plus
. 2022 May;
6(5):e10617.
PMID: 35509631
For many years there has been a keen interest in developing regenerative treatment for temporomandibular joint-osteoarthritis (TMJ-OA). Currently, there is no consensus treatment due to the limited self-healing ability of...
4.
Silva L, Doyle A, Greenwell-Wild T, Dutzan N, Tran C, Abusleme L, et al.
Science
. 2021 Dec;
374(6575):eabl5450.
PMID: 34941394
Tissue-specific cues are critical for homeostasis at mucosal barriers. Here, we report that the clotting factor fibrin is a critical regulator of neutrophil function at the oral mucosal barrier. We...
5.
Chavez M, Chu E, Kram V, de Castro L, Somerman M, Foster B
JBMR Plus
. 2021 Mar;
5(3):e10474.
PMID: 33778330
Micro-computed tomography (μCT) has become essential for analysis of mineralized as well as nonmineralized tissues and is therefore widely applicable in the life sciences. However, lack of standardized approaches and...
6.
Fernandez-Ruiz R, Garcia-Alaman A, Esteban Y, Mir-Coll J, Serra-Navarro B, Fontcuberta-PiSunyer M, et al.
Nat Commun
. 2020 Nov;
11(1):5982.
PMID: 33239617
Expanding the mass of pancreatic insulin-producing beta cells through re-activation of beta cell replication has been proposed as a therapy to prevent or delay the appearance of diabetes. Pancreatic beta...
7.
Kram V, Jani P, Kilts T, Li L, Chu E, Young M
J Struct Biol
. 2020 Sep;
212(3):107627.
PMID: 32950603
Biglycan (Bgn) and Fibromodulin (Fmod) are small leucine rich proteoglycans (SLRPs) which are abundant in the extra-cellular matrix (ECM) of mineralized tissues. We have previously generated a Bgn/Fmod double knock-out...
8.
Pham H, Kram V, Dar Q, Komori T, Ji Y, Mohassel P, et al.
Sci Rep
. 2020 Aug;
10(1):13749.
PMID: 32792616
Type VI collagen is well known for its role in muscular disorders, however its function in bone is still not well understood. To examine its role in bone we analyzed...
9.
Kram V, Shainer R, Jani P, Meester J, Loeys B, Young M
J Histochem Cytochem
. 2020 Jul;
68(11):747-762.
PMID: 32623936
Small leucine rich proteoglycans (SLRPs), including Biglycan, have key roles in many organ and tissue systems. The goal of this article is to review the function of Biglycan and other...
10.
Verma S, Leikina E, Melikov K, Gebert C, Kram V, Young M, et al.
J Biol Chem
. 2017 Nov;
293(1):254-270.
PMID: 29101233
Bone-resorbing multinucleated osteoclasts that play a central role in the maintenance and repair of our bones are formed from bone marrow myeloid progenitor cells by a complex differentiation process that...