Vanessa Rodriguez-Fanjul

We report the synthesis of a macrocyclic poly(ethylene oxide) (PEO) connected by one [Ru(bpy)] unit (where bpy = 2,2'-bipyridine), a photoactive metal complex that provides photosensitivity and potential biomedical applications...

Complexes of the formula [Os(η-arene)(,-phenylpyridine)Z] (where Z is chlorido or a tethered oxygen) undergo very fast Os-Z hydrolysis (<5 min), and the high basicity of the coordinated water molecule of...

Colorectal cancer is the second most common cancer in women, the third in men, and an important cause of cancer-related mortality. Recurrence and the development of chemotherapy resistance are major...

Aquation is often acknowledged as a necessary step for metallodrug activity inside the cell. Hemilabile ligands can be used for reversible metallodrug activation. We report a new family of osmium(ii)...

We present four new organometallic half-sandwich iridium(III) complexes of formula [Ir(η:κ-CMeCHpy)(N,N)](PF), bearing a N,N-chelating ligand [ethylenediamine (en), ; 1,3-diaminopropane (dap), ; 2,2'-bipyridine (bipy), ; 1,10-phenanthroline (phen), ]; and a derivatized...

Six complexes of formula [Ir(η:κ-CMeCHpy)(C,N)]PF, where CMeCHpy is 2-((2,3,4,5-tetramethylcyclopentadienyl)methyl)pyridine, and C,N is 2-phenylpyridine (), 7,8-benzoquinoline (), 1-phenylisoquinoline (), 2-(-tolyl)pyridine (), 4-chloro-2-phenylquinoline (), or 2-(2,4-difluorophenyl)pyridine (), have been synthesized. The cyclopentadienyl...

The iridium half-sandwich complex [Ir(η :κ -C Me CH py)(2-phenylpyridine)]PF is highly cytotoxic: 15-250× more potent than clinically used cisplatin in several cancer cell lines. We have developed a correlative...

Gold(III) compounds have received increasing attention in cancer research. Three gold complexes of general formula [AuL]Cl, where L is benzil bis(thiosemicarbazonate), compound 1, benzil bis(4-methyl-3-thiosemicarbazonate), compound 2, or benzil bis(4-cyclohexyl-3-thiosemicarbazonate),...

Human gliomas harbour cancer stem cells (CSCs) that evolve along the course of the disease, forming highly heterogeneous subpopulations within the tumour mass. These cells possess self-renewal properties and appear...

Treatment of non-small cell lung cancer (NSCLC) with cisplatin has a level of antitumor activity still modest. We have shown previously that MKP1/DUSP1 inhibits cisplatin-induced apoptosis in NSCLC cells and...