Valerie Pestinger
Overview
Explore the profile of Valerie Pestinger including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
385
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0
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Recent Articles
1.
Clare C, Pestinger V, Kwong W, Tutt D, Xu J, Byrne H, et al.
Int J Mol Sci
. 2021 Mar;
22(4).
PMID: 33673278
One-carbon (1C) metabolism provides methyl groups for the synthesis and/or methylation of purines and pyrimidines, biogenic amines, proteins, and phospholipids. Our understanding of how 1C pathways operate, however, pertains mostly...
2.
Hallam S, Stockton J, Bryer C, Whalley C, Pestinger V, Youssef H, et al.
Sci Rep
. 2020 Nov;
10(1):18900.
PMID: 33144643
Colorectal Peritoneal metastases (CPM) develop in 15% of colorectal cancers. Cytoreductive surgery and heated intraperitoneal chemotherapy (CRS & HIPEC) is the current standard of care in selected patients with limited...
3.
Pestinger V, Smith M, Sillo T, Findlay J, Laes J, Martin G, et al.
Mol Diagn Ther
. 2020 Jun;
24(4):505.
PMID: 32572786
This article was originally published under a [CC BY NC 4.0] license.
4.
Pestinger V, Smith M, Sillo T, Findlay J, Laes J, Martin G, et al.
Mol Diagn Ther
. 2020 Apr;
24(3):339-349.
PMID: 32306292
Introduction: The identification of tumour mutational burden (TMB) as a biomarker of response to programmed cell death protein 1 (PD-1) immunotherapy has necessitated the development of genomic assays to measure...
5.
Kroeze L, de Voer R, Kamping E, von Rhein D, Jansen E, Hermsen M, et al.
J Mol Diagn
. 2020 Mar;
22(6):757-769.
PMID: 32205293
Stratification of patients for targeted and immune-based therapies requires extensive genomic profiling that enables sensitive detection of clinically relevant variants and interrogation of biomarkers, such as tumor mutational burden (TMB)...
6.
Kleeman S, Koelzer V, Jones H, Gil Vazquez E, Davis H, East J, et al.
Gut
. 2019 Sep;
69(6):1092-1103.
PMID: 31563876
Objective: Pathological Wnt pathway activation is a conserved hallmark of colorectal cancer. Wnt-activating mutations can be divided into: i) ligand-independent (LI) alterations in intracellular signal transduction proteins (, β-catenin), causing...
7.
Beggs A, Mehta S, Deeks J, James J, Caldwell G, Dilworth M, et al.
EBioMedicine
. 2018 Nov;
39:265-271.
PMID: 30473377
Background: Chronic inflammation caused by ulcerative colitis (UC) causes a pro-neoplastic drive in the inflamed colon, leading to a markedly greater risk of invasive malignancy compared to the general population....
8.
Steegers-Theunissen R, Twigt J, Pestinger V, Sinclair K
Hum Reprod Update
. 2013 Aug;
19(6):640-55.
PMID: 23959022
BACKGROUND Most reproductive failures originate during the periconceptional period and are influenced by the age and the lifestyle of parents-to-be. We advance the hypothesis that these failures can arise as...
9.
Rios-Avila L, Pestinger V, Zempleni J
J Nutr Biochem
. 2011 Dec;
23(12):1559-64.
PMID: 22192339
Holocarboxylase synthetase (HCS) catalyzes the binding of biotin to lysine (K) residues in histones H3 and H4. Histone biotinylation marks are enriched in repressed loci, including retrotransposons. Preliminary studies suggested...
10.
Kuroishi T, Rios-Avila L, Pestinger V, Wijeratne S, Zempleni J
Mol Genet Metab
. 2011 Sep;
104(4):537-45.
PMID: 21930408
Previous studies suggest that histones H3 and H4 are posttranslationally modified by binding of the vitamin biotin, catalyzed by holocarboxylase synthetase (HCS). Albeit a rare epigenetic mark, biotinylated histones were...