Andrew D Beggs
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Explore the profile of Andrew D Beggs including associated specialties, affiliations and a list of published articles.
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93
Citations
2249
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Recent Articles
1.
Middleton G, Robbins H, Fletcher P, Savage J, Mehmi M, Summers Y, et al.
NPJ Precis Oncol
. 2025 Mar;
9(1):67.
PMID: 40069402
There are no current stratified medicine options for STK11-deficient NSCLC. STK11 loss mediates mTORC activation, GLUT1 up-regulation and increased glycolysis. This metabolic reprogramming might represent a therapeutic vulnerability targetable with...
2.
Platt J, Pennycook S, Muthoo C, Westwood A, Frood R, Beggs A, et al.
Eur J Radiol
. 2025 Feb;
185:112000.
PMID: 39978239
In the era of precision oncology, systemic therapies for colon cancer are becoming increasingly biomarker-led, with implications for patients in the neoadjuvant, adjuvant and metastatic settings. As the landscape for...
3.
Al-Shakhshir S, Quraishi M, Mullish B, Patel A, Vince A, Rowe A, et al.
BMJ Open
. 2025 Jan;
15(1):e095392.
PMID: 39762111
Introduction: Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). The strong association between gut and liver inflammation has driven several pathogenic hypotheses to which...
4.
Schoenpflug L, Chatzipli A, Sirinukunwattana K, Richman S, Blake A, Robineau J, et al.
J Pathol
. 2024 Dec;
265(2):184-197.
PMID: 39710952
Tumour content plays a pivotal role in directing the bioinformatic analysis of molecular profiles such as copy number variation (CNV). In clinical application, tumour purity estimation (TPE) is achieved either...
5.
Quraishi M, Cheesbrough J, Rimmer P, Mullish B, Sharma N, Efstathiou E, et al.
J Crohns Colitis
. 2024 Dec;
19(2).
PMID: 39673746
Background: We conducted a single-arm interventional study, to explore mucosal changes associated with clinical remission under oral vancomycin (OV) treatment, in primary sclerosing cholangitis-associated inflammatory bowel disease (PSC-IBD); NCT05376228. Methods:...
6.
de Bruijn S, Panneman D, Weisschuh N, Cadena E, Boonen E, Holtes L, et al.
Front Genet
. 2024 Nov;
15:1469686.
PMID: 39507620
Introduction: Autosomal dominant retinitis pigmentosa type 17 (adRP, type RP17) is caused by complex structural variants (SVs) affecting a locus on chromosome 17 (chr17q22). The SVs disrupt the 3D regulatory...
7.
Leung E, Robbins H, Zaman S, Lal N, Morton D, Dew L, et al.
Br J Cancer
. 2024 Oct;
131(11):1805-1813.
PMID: 39478124
Background: The 100,000 Genomes Project established infrastructure for Whole Genome Sequencing (WGS) in the United Kingdom. Methods: A retrospective study of cancer patients recruited to the 100,000 Genomes Project by...
8.
Kumar A, Quraishi M, Al-Hassi H, Elasrag M, Segal J, Jain M, et al.
Inflamm Bowel Dis
. 2024 Oct;
31(2):539-551.
PMID: 39422655
Background: While surgery plays a pivotal role in the management of ileal Crohn's disease, the risk of endoscopic recurrence following an ileocaecal resection can be greater than 65% within 12...
9.
Payne K, Brotherwood P, Suriyanarayanan H, Brooks J, Batis N, Beggs A, et al.
Front Oncol
. 2024 Jun;
14:1374816.
PMID: 38846976
Background: As circulating tumour DNA (ctDNA) liquid biopsy analysis is increasingly incorporated into modern oncological practice, establishing the impact of genomic intra-tumoural heterogeneity (ITH) upon data output is paramount. Despite...
10.
Halle-Smith J, Pearce H, Nicol S, Hall L, Powell-Brett S, Beggs A, et al.
Cancers (Basel)
. 2024 Mar;
16(5).
PMID: 38473357
The systemic and local immunosuppression exhibited by pancreatic ductal adenocarcinoma (PDAC) contributes significantly to its aggressive nature. There is a need for a greater understanding of the mechanisms behind this...