Valeria Casavola
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Explore the profile of Valeria Casavola including associated specialties, affiliations and a list of published articles.
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47
Citations
1390
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Recent Articles
1.
Guerra L, Favia M, Di Gioia S, Laselva O, Bisogno A, Casavola V, et al.
Expert Opin Drug Discov
. 2020 Apr;
15(8):873-891.
PMID: 32290721
Introduction: Cystic Fibrosis (CF) is caused by mutations in the (CFTR) gene. The most common mutation, , induces protein misprocessing and loss of CFTR function. The discovery through studies of...
2.
Favia M, Gallo C, Guerra L, De Venuto D, Diana A, Polizzi A, et al.
Int J Mol Sci
. 2020 Apr;
21(7).
PMID: 32244302
The treatment of cystic fibrosis (CF) patients homozygous for the mutation with Orkambi, a combination of a corrector (lumacaftor) and a potentiator (ivacaftor) of the mutated CFTR protein, resulted in...
3.
Biondani G, Zeeberg K, Greco M, Cannone S, Dando I, Dalla Pozza E, et al.
FEBS J
. 2019 Sep;
286(17):3504.
PMID: 31475461
No abstract available.
4.
Biondani G, Zeeberg K, Greco M, Cannone S, Dando I, Dalla Pozza E, et al.
FEBS J
. 2018 Apr;
285(11):2104-2124.
PMID: 29660229
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. Its aggressiveness is driven by an intense fibrotic desmoplastic reaction in which the increasingly collagen I-rich extracellular matrix (ECM)...
5.
Laselva O, Molinski S, Casavola V, Bear C
Mol Pharmacol
. 2018 Apr;
93(6):612-618.
PMID: 29618585
The most common cystic fibrosis causing mutation is deletion of phenylalanine at position 508 (F508del), a mutation that leads to protein misassembly with defective processing. Small molecule corrector compounds: VX-809...
6.
Carbone A, Zefferino R, Beccia E, Casavola V, Castellani S, Di Gioia S, et al.
Stem Cells Int
. 2018 Mar;
2018:1203717.
PMID: 29531530
We previously found that human amniotic mesenchymal stem cells (hAMSCs) in coculture with CF immortalised airway epithelial cells (CFBE41o- line, CFBE) on Transwell® filters acquired an epithelial phenotype and led...
7.
Muzzachi S, Guerra L, Martino N, Favia M, Punzi G, Silvestre F, et al.
Reproduction
. 2018 Mar;
155(5):433-445.
PMID: 29491124
Sperm motility, a feature essential for fertilization, is influenced by intracellular pH (pH) homeostasis. Several mechanisms are involved in pH regulation, among which sodium-hydrogen exchangers (NHEs), a family of integral...
8.
Guerra L, DOria S, Favia M, Castellani S, Santostasi T, Polizzi A, et al.
Pediatr Pulmonol
. 2017 Apr;
52(7):900-908.
PMID: 28445004
Aim: The Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) potentiator ivacaftor (Kalydeco®) improves clinical outcome in G551D cystic fibrosis (CF) patients. Here, we have investigated whether ivacaftor has a clinical impact...
9.
Castellani S, Favia M, Guerra L, Carbone A, Abbattiscianni A, Di Gioia S, et al.
Histol Histopathol
. 2016 Nov;
32(5):445-459.
PMID: 27834058
Cystic fibrosis (CF), one of the most common genetic disorders affecting primarily Caucasians, is due to mutations in the CF Transmembrane Conductance Regulator (CFTR) gene, encoding for a chloride channel...
10.
Gorrieri G, Scudieri P, Caci E, Schiavon M, Tomati V, Sirci F, et al.
Sci Rep
. 2016 Oct;
6:36016.
PMID: 27786259
Goblet cell hyperplasia, a feature of asthma and other respiratory diseases, is driven by the Th-2 cytokines IL-4 and IL-13. In human bronchial epithelial cells, we find that IL-4 induces...