Stephan J Reshkin
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Explore the profile of Stephan J Reshkin including associated specialties, affiliations and a list of published articles.
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56
Citations
2183
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Recent Articles
1.
Carvalho T, Audero M, Greco M, Ardone M, Maggi T, Mallamaci R, et al.
Cells
. 2024 May;
13(9.
PMID: 38727266
Background: Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease with high mortality due to early metastatic dissemination and high chemoresistance. All these factors are favored by its extracellular matrix (ECM)-rich...
2.
Reshkin S, Cardone R, Koltai T
Cells
. 2024 Apr;
13(7.
PMID: 38607041
Pancreatic cancer is a highly lethal disease with a 5-year survival rate of around 11-12%. Surgery, being the treatment of choice, is only possible in 20% of symptomatic patients. The...
3.
Tavares-Valente D, Cannone S, Greco M, Carvalho T, Baltazar F, Queiros O, et al.
Cancers (Basel)
. 2023 Aug;
15(15).
PMID: 37568684
Pancreatic ductal adenocarcinoma (PDAC) has a 5-year survival rate of less than 10 percent largely due to the intense fibrotic desmoplastic reaction, characterized by high levels of extracellular matrix (ECM)...
4.
Di Molfetta D, Cannone S, Greco M, Caroppo R, Piccapane F, Carvalho T, et al.
Int J Mol Sci
. 2023 Jul;
24(13).
PMID: 37445810
Intracellular pH (pHi) regulation is a challenge for the exocrine pancreas, where the luminal secretion of bicarbonate-rich fluid is accompanied by interstitial flows of acid. This acid-base transport requires a...
5.
Audero M, Carvalho T, Ruffinatti F, Loeck T, Yassine M, Chinigo G, et al.
Cancers (Basel)
. 2023 May;
15(9).
PMID: 37174038
Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by an acidic microenvironment, which contributes to therapeutic failure. So far there is a lack of knowledge with respect to the role of the...
6.
Harguindey S, Reshkin S, Alfarouk K
Cancers (Basel)
. 2023 Jan;
15(2).
PMID: 36672490
A century ago, Otto Warburg published that aerobic glycolysis and the respiratory impairment of cells were the prime cause of cancer, a phenomenon that since then has been known as...
7.
Cappellesso F, Orban M, Shirgaonkar N, Berardi E, Serneels J, Neveu M, et al.
Nat Cancer
. 2022 Dec;
3(12):1464-1483.
PMID: 36522548
Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that favors cancer progression, therapy resistance and immune evasion. By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma...
8.
Harguindey S, Alfarouk K, Polo Orozco J, Reshkin S, Devesa J
Int J Mol Sci
. 2022 Mar;
23(5).
PMID: 35269597
The pH-related metabolic paradigm has rapidly grown in cancer research and treatment. In this contribution, this recent oncological perspective has been laterally assessed for the first time in order to...
9.
Carvalho T, Di Molfetta D, Greco M, Koltai T, Alfarouk K, Reshkin S, et al.
Cancers (Basel)
. 2021 Dec;
13(23).
PMID: 34885243
Currently, the median overall survival of PDAC patients rarely exceeds 1 year and has an overall 5-year survival rate of about 9%. These numbers are anticipated to worsen in the...
10.
Alfarouk K, Alqahtani S, Alshahrani S, Morgenstern J, Supuran C, Reshkin S
J Enzyme Inhib Med Chem
. 2021 Sep;
36(1):2010-2015.
PMID: 34517737
Tumours reprogram their metabolism to acquire an evolutionary advantage over normal cells. However, not all such metabolic pathways support energy production. An example of these metabolic pathways is the Methylglyoxal...