Vadim V Fedorov
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Explore the profile of Vadim V Fedorov including associated specialties, affiliations and a list of published articles.
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98
Citations
3034
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Recent Articles
1.
Zhao J, Sharma R, Kalyanasundaram A, Kennelly J, Bai J, Li N, et al.
PLoS Comput Biol
. 2023 Dec;
19(12):e1011708.
PMID: 38109436
The sinoatrial node (SAN), the primary pacemaker of the heart, is responsible for the initiation and robust regulation of sinus rhythm. 3D mapping studies of the ex-vivo human heart suggested...
2.
Zhao J, Kennelly J, Nalar A, Kulathilaka A, Sharma R, Bai J, et al.
Interface Focus
. 2023 Dec;
13(6):20230044.
PMID: 38106912
Persistent atrial fibrillation (AF) is not effectively treated due to a lack of adequate tools for identifying patient-specific AF substrates. Recent studies revealed that in 30-50% of patients, persistent AF...
3.
Li N, Hansen B, Kennelly J, Kalyanasundaram A, Kanaan A, Simonetti O, et al.
Circ Arrhythm Electrophysiol
. 2023 Mar;
16(4):e011528.
PMID: 36916270
No abstract available.
4.
Kalyanasundaram A, Li N, Augostini R, Weiss R, Hummel J, Fedorov V
Heart Rhythm
. 2022 Sep;
20(1):122-133.
PMID: 36113768
The sinoatrial node (SAN) is the primary pacemaker of the human heart. It is a single, elongated, 3-dimensional (3D) intramural fibrotic structure located at the junction of the superior vena...
5.
Li N, Artiga E, Kalyanasundaram A, Hansen B, Webb A, Pietrzak M, et al.
Sci Rep
. 2021 Sep;
11(1):19328.
PMID: 34588502
Heart failure (HF) is frequently accompanied with the sinoatrial node (SAN) dysfunction, which causes tachy-brady arrhythmias and increased mortality. MicroRNA (miR) alterations are associated with HF progression. However, the transcriptome...
6.
Kalyanasundaram A, Li N, Gardner M, Artiga E, Hansen B, Webb A, et al.
Circulation
. 2021 Apr;
144(2):126-143.
PMID: 33874740
Background: Up to 50% of the adult human sinoatrial node (SAN) is composed of dense connective tissue. Cardiac diseases including heart failure (HF) may increase fibrosis within the SAN pacemaker...
7.
Mikhailov A, Kalyanasundaram A, Li N, Scott S, Artiga E, Subr M, et al.
J Mol Cell Cardiol
. 2020 Nov;
151:56-71.
PMID: 33130148
Atrial fibrillation (AF) occurrence and maintenance is associated with progressive remodeling of electrophysiological (repolarization and conduction) and 3D structural (fibrosis, fiber orientations, and wall thickness) features of the human atria....
8.
Petkova M, Atkinson A, Yanni J, Stuart L, Aminu A, Ivanova A, et al.
J Am Heart Assoc
. 2020 Oct;
9(20):e016590.
PMID: 33059532
Background The sinus node (SN) is the primary pacemaker of the heart. SN myocytes possess distinctive action potential morphology with spontaneous diastolic depolarization because of a unique expression of ion...
9.
Mesirca P, Fedorov V, Hund T, Torrente A, Bidaud I, Mohler P, et al.
Annu Rev Pharmacol Toxicol
. 2020 Oct;
61:757-778.
PMID: 33017571
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's inability to generate a normal...
10.
Hansen B, Zhao J, Helfrich K, Li N, Iancau A, Zolotarev A, et al.
J Am Heart Assoc
. 2020 Oct;
9(19):e017789.
PMID: 33006292
Background Atrial fibrillation (AF) driver mechanisms are obscured to clinical multielectrode mapping approaches that provide partial, surface-only visualization of unstable 3-dimensional atrial conduction. We hypothesized that transient modulation of refractoriness...