Vadim Molodtsov
Overview
Explore the profile of Vadim Molodtsov including associated specialties, affiliations and a list of published articles.
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24
Citations
488
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Recent Articles
1.
You L, Wang C, Molodtsov V, Kuznedelov K, Miao X, Wenck B, et al.
Nature
. 2024 Sep;
635(8037):229-236.
PMID: 39322680
The ribonuclease FttA (also known as aCPSF and aCPSF1) mediates factor-dependent transcription termination in archaea. Here we report the structure of a Thermococcus kodakarensis transcription pre-termination complex comprising FttA, Spt4,...
2.
Molodtsov V, Wang C, Zhang J, Kaelber J, Blaha G, Ebright R
Nat Struct Mol Biol
. 2024 Aug;
31(12):1932-1941.
PMID: 39117885
The NusG paralog RfaH mediates bacterial transcription-translation coupling in genes that contain a DNA sequence element, termed an ops site, required for pausing RNA polymerase (RNAP) and for loading RfaH...
3.
Wang C, Molodtsov V, Kaelber J, Blaha G, Ebright R
bioRxiv
. 2024 Jul;
PMID: 39071276
Structures recently have been reported of molecular assemblies that mediate transcription-translation coupling in . In these molecular assemblies, termed "coupled transcription-translation complexes" or "TTC-B", RNA polymerase (RNAP) interacts directly with...
4.
Molodtsov V, Wang C, Kaelber J, Blaha G, Ebright R
bioRxiv
. 2023 Nov;
PMID: 37986937
One Sentence Summary: Cryo-EM reveals the structural basis of transcription-translation coupling by RfaH.
5.
Wang C, Molodtsov V, Sanders T, Marshall C, Firlar E, Kaelber J, et al.
bioRxiv
. 2023 Aug;
PMID: 37609354
One Sentence Summary: Cryo-EM reveals the structure of the archaeal FttA pre-termination complex.
6.
Molodtsov V, Wang C, Firlar E, Kaelber J, Ebright R
Nature
. 2023 Jan;
614(7947):367-374.
PMID: 36697824
Rho is a ring-shaped hexameric ATP-dependent molecular motor. Together with the transcription elongation factor NusG, Rho mediates factor-dependent transcription termination and transcription-translation-coupling quality control in Escherichia coli. Here we report...
7.
Lan T, Ganapathy U, Sharma S, Ahn Y, Zimmerman M, Molodtsov V, et al.
Angew Chem Int Ed Engl
. 2022 Oct;
61(45):e202211498.
PMID: 36222275
Rifamycin antibiotics are a valuable class of antimicrobials for treating infections by mycobacteria and other persistent bacteria owing to their potent bactericidal activity against replicating and non-replicating pathogens. However, the...
8.
Pukhrambam C, Molodtsov V, Kooshkbaghi M, Tareen A, Vu H, Skalenko K, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(23):e2201301119.
PMID: 35653571
In σ-dependent transcriptional pausing, the transcription initiation factor σ, translocating with RNA polymerase (RNAP), makes sequence-specific protein–DNA interactions with a promoter-like sequence element in the transcribed region, inducing pausing. It...
9.
Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, et al.
J Med Chem
. 2022 Feb;
65(6):4481-4495.
PMID: 35175750
TNP-2198, a stable conjugate of a rifamycin pharmacophore and a nitroimidazole pharmacophore, has been designed, synthesized, and evaluated as a novel dual-targeted antibacterial agent for the treatment of microaerophilic and...
10.
Qayyum M, Molodtsov V, Renda A, Murakami K
J Biol Chem
. 2021 Nov;
297(6):101404.
PMID: 34774797
After transcription termination, cellular RNA polymerases (RNAPs) are occasionally trapped on DNA, impounded in an undefined post-termination complex (PTC), limiting the free RNAP pool and subsequently leading to inefficient transcription....