Richard H Ebright
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Explore the profile of Richard H Ebright including associated specialties, affiliations and a list of published articles.
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107
Citations
4598
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Recent Articles
1.
Pleomorphic effects of three small-molecule inhibitors on transcription elongation by RNA polymerase
Herrera-Asmat O, Tong A, Lin W, Kong T, Del Valle J, Guerra D, et al.
bioRxiv
. 2025 Feb;
PMID: 39975155
The RNA polymerase (MtbRNAP) is the target of the first-line anti-tuberculosis inhibitor rifampin, however, the emergence of rifampin resistance necessitates the development of new antibiotics. Here, we communicate the first...
2.
Anwar A, Elbatrawi Y, Degen D, Ebright R, Del Valle J
Org Lett
. 2024 Nov;
26(46):10056-10060.
PMID: 39531363
We report the synthesis of the antimicrobial cyclodepsipeptides marformycin A () and marformycin D () using a solid-phase approach. A scalable solution-phase synthesis of the γ-hydroxypiperazic acid subunit in ,...
3.
You L, Wang C, Molodtsov V, Kuznedelov K, Miao X, Wenck B, et al.
Nature
. 2024 Sep;
635(8037):229-236.
PMID: 39322680
The ribonuclease FttA (also known as aCPSF and aCPSF1) mediates factor-dependent transcription termination in archaea. Here we report the structure of a Thermococcus kodakarensis transcription pre-termination complex comprising FttA, Spt4,...
4.
Molodtsov V, Wang C, Zhang J, Kaelber J, Blaha G, Ebright R
Nat Struct Mol Biol
. 2024 Aug;
31(12):1932-1941.
PMID: 39117885
The NusG paralog RfaH mediates bacterial transcription-translation coupling in genes that contain a DNA sequence element, termed an ops site, required for pausing RNA polymerase (RNAP) and for loading RfaH...
5.
Wang C, Molodtsov V, Kaelber J, Blaha G, Ebright R
bioRxiv
. 2024 Jul;
PMID: 39071276
Structures recently have been reported of molecular assemblies that mediate transcription-translation coupling in . In these molecular assemblies, termed "coupled transcription-translation complexes" or "TTC-B", RNA polymerase (RNAP) interacts directly with...
6.
Nova I, Craig J, Mazumder A, Laszlo A, Derrington I, Noakes M, et al.
Proc Natl Acad Sci U S A
. 2024 Jul;
121(29):e2321017121.
PMID: 38990947
RNA polymerases (RNAPs) carry out the first step in the central dogma of molecular biology by transcribing DNA into RNA. Despite their importance, much about how RNAPs work remains unclear,...
7.
Ebright R, MacIntyre R, Dudley J, Butler C, Goffinet A, Hammond E, et al.
J Virol
. 2024 Mar;
98(4):e0023724.
PMID: 38477586
No abstract available.
8.
Molodtsov V, Wang C, Kaelber J, Blaha G, Ebright R
bioRxiv
. 2023 Nov;
PMID: 37986937
One Sentence Summary: Cryo-EM reveals the structural basis of transcription-translation coupling by RfaH.
9.
Anwar A, Cain C, Garza M, Degen D, Ebright R, Del Valle J
ChemMedChem
. 2023 Sep;
19(1):e202300474.
PMID: 37751316
Pseudouridimycin (PUM) is a microbially produced C-nucleoside dipeptide that selectively targets the nucleotide addition site of bacterial RNA polymerase (RNAP) and that has a lower rate of spontaneous resistance emergence...
10.
Wang C, Molodtsov V, Sanders T, Marshall C, Firlar E, Kaelber J, et al.
bioRxiv
. 2023 Aug;
PMID: 37609354
One Sentence Summary: Cryo-EM reveals the structure of the archaeal FttA pre-termination complex.