V M Lakshmi
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Explore the profile of V M Lakshmi including associated specialties, affiliations and a list of published articles.
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40
Citations
176
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Recent Articles
1.
Zenser T, Lakshmi V, Hsu F, Davis B
Drug Metab Dispos
. 2001 Mar;
29(4 Pt 1):401-6.
PMID: 11259323
Aromatic amine sulfinamide adducts of hemoglobin are biomarkers of exposure and evidence for cytochrome P-450 N-hydroxylation. The possible peroxidatic formation of an N-acetylbenzidine (ABZ) sulfinamide adduct by methemoglobin was examined....
2.
Lakshmi V, Hsu F, Davis B, Zenser T
Chem Res Toxicol
. 2001 Mar;
14(3):312-8.
PMID: 11258981
A close association has been reported for certain types of cancers influenced by aromatic amines and infection/inflammation. Reactive nitric oxygen species (RNOS), components of the inflammatory response, are bactericidal and...
3.
Lakshmi V, Hsu F, Davis B, Zenser T
Chem Res Toxicol
. 2000 Sep;
13(9):891-9.
PMID: 10995262
Nitrating reactive nitric oxygen species (RNOS) elicit many of the deleterious effects of the inflammatory response. Their high reactivity and short half-life make RNOS analysis difficult. Reaction of acetaminophen (APAP)...
4.
Lakshmi V, Hsu F, Davis B, Zenser T
Chem Res Toxicol
. 2000 Aug;
13(8):785-92.
PMID: 10956067
N'-(3'-Monophosphodeoxyguanosin-8-yl)-N-acetylbenzidine (dGp-ABZ) is the major adduct in exfoliated urothelial cells and in peripheral white blood cells of workers exposed to benzidine. This study was designed to assess the metabolic pathways...
5.
Lakshmi V, Hsu F, McGarry A, Davis B, Zenser T
Toxicol Sci
. 2000 Mar;
53(2):202-12.
PMID: 10696768
Hypochlorous acid (HOCl), a chemically reactive oxidant, is an important component of the inflammatory response and may contribute to carcinogenesis. This study assessed the possible activation of N-acetylbenzidine (ABZ) by...
6.
Lakshmi V, Hsu F, Davis B, Zenser T
Chem Res Toxicol
. 2000 Feb;
13(2):96-102.
PMID: 10688533
Arylamine-hemoglobin conjugates identified as sulfinamides are considered dosimeters for the bioavailability of metabolically formed N-oxidation products. This report considers peroxidation as an alternative pathway for aromatic amine metabolism and examines...
7.
Ciotti M, Lakshmi V, Basu N, Davis B, Owens I, Zenser T
Carcinogenesis
. 1999 Oct;
20(10):1963-9.
PMID: 10506112
Although glucuronidation is considered a necessary step in aromatic amine-induced bladder cancer, the specific enzymes involved are not known. This study assessed the capacity of five different human recombinant UDP-glucuronosyltransferases...
8.
Zenser T, Lakshmi V, Davis B
Drug Metab Dispos
. 1999 Aug;
27(9):1064-7.
PMID: 10460807
Individuals exposed to carcinogenic aromatic amines excrete arylamine N- and O-glucuronide metabolites. This study assessed the susceptibility of selected glucuronides to hydrolysis by human and Escherichia coli beta-glucuronidase. N- or...
9.
Zenser T, Lakshmi V, Hsu F, Davis B
J Biol Chem
. 1999 May;
274(21):14850-6.
PMID: 10329684
Synthesis of prostaglandin H2 by prostaglandin H synthase (PHS) results in a two-electron oxidation of the enzyme. An active reduced enzyme is regenerated by reducing cofactors, which become oxidized. This...
10.
Zenser T, Lakshmi V, Davis B
Drug Metab Dispos
. 1998 Sep;
26(9):856-9.
PMID: 9733663
Workers exposed to high levels of benzidine have a 100-fold increased incidence of bladder cancer. This review evaluates the overall metabolism of benzidine to determine pathways important to initiation of...