V Dolezal
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Explore the profile of V Dolezal including associated specialties, affiliations and a list of published articles.
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123
Citations
352
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Recent Articles
1.
Lyukmanova E, Shulepko M, Shenkarev Z, Bychkov M, Paramonov A, Chugunov A, et al.
Sci Rep
. 2016 Aug;
6:30698.
PMID: 27485575
Human-secreted Ly-6/uPAR-related protein-2 (SLURP-2) regulates the growth and differentiation of epithelial cells. Previously, the auto/paracrine activity of SLURP-2 was considered to be mediated via its interaction with the α3β2 subtype...
2.
Jakubik J, Santruckova E, Randakova A, Janickova H, Zimcik P, Rudajev V, et al.
Physiol Res
. 2014 Feb;
63(Suppl 1):S177-89.
PMID: 24564657
Muscarinc receptor-mediated signaling takes part in many physiological functions ranging from complex higher nervous activity to vegetative responses. Specificity of action of the natural muscarinic agonist acetylcholine is effected by...
3.
Jakubik J, Janickova H, El-Fakahany E, Dolezal V
Br J Pharmacol
. 2010 Oct;
162(5):1029-44.
PMID: 20958290
Background And Purpose: Conventional determination of agonist efficacy at G-protein coupled receptors is measured by stimulation of guanosine-5'-γ-thiotriphosphate (GTPγS) binding. We analysed the role of guanosine diphosphate (GDP) in the...
4.
Jakubik J, Michal P, Machova E, Dolezal V
Physiol Res
. 2008 May;
57 Suppl 3:S39-S47.
PMID: 18481916
There are five subtypes of muscarinic receptors that serve various important physiological functions in the central nervous system and the periphery. Mental functions like attention, learning, and memory are attributed...
5.
Machova E, Jakubik J, El-Fakahany E, Dolezal V
J Pharmacol Exp Ther
. 2007 Apr;
322(1):316-23.
PMID: 17446301
We studied the effects of 3-[3-hexyloxy-1,2,5-thiadiazo-4-yl]-1,2,5,6-tetrahydro-1-methylpyridine (xanomeline) wash-resistant binding on presynaptic muscarinic regulation of electrically evoked [(3)H]acetylcholine (ACh) release from rat brain slices. In both cortical and striatal tissues that...
6.
Machova E, Jakubik J, Michal P, Oksman M, Iivonen H, Tanila H, et al.
Neurobiol Aging
. 2006 Dec;
29(3):368-78.
PMID: 17140703
We assessed the integrity of cholinergic neurotransmission in parietal cortex of young adult (7 months) and aged (17 months) transgenic APPswe/PS1dE9 female mice compared to littermate controls. Choline acetyltransferase and...
7.
Michal P, El-Fakahany E, Dolezal V
J Pharmacol Exp Ther
. 2006 Oct;
320(2):607-14.
PMID: 17065363
Muscarinic M(2) receptors preferentially couple with the G(i/o) class of G-proteins to inhibit cAMP synthesis. However, they can also stimulate net synthesis of cAMP and inositol phosphate (IP) accumulation. We...
8.
Jakubik J, Krejci A, Dolezal V
J Pharmacol Exp Ther
. 2005 Jan;
313(2):688-96.
PMID: 15647330
We have investigated allosteric interactions of four closely related strychnine-like substances: Wieland-Gumlich aldehyde (WGA), propargyl Wieland-Gumlich aldehyde, strychnine, and brucine with N-methylscopolamine (NMS) on M(3) subtype of muscarinic receptor genetically...
9.
Krejci A, Michal P, Jakubik J, Ricny J, Dolezal V
Physiol Res
. 2004 May;
53 Suppl 1:S131-40.
PMID: 15119944
Muscarinic acetylcholine receptors mediate transmission of an extracellular signal represented by released acetylcholine to neuronal or effector cells. There are five subtypes of closely homologous muscarinic receptors which are coupled...
10.
Lazareno S, Dolezal V, Popham A, Birdsall N
Mol Pharmacol
. 2004 Jan;
65(1):257-66.
PMID: 14722259
Thiochrome (2,7-dimethyl-5H-thiachromine-8-ethanol), an oxidation product and metabolite of thiamine, has little effect on the equilibrium binding of l-[3H]N-methyl scopolamine ([3H]NMS) to the five human muscarinic receptor subtypes (M1-M5) at concentrations...