V Dhanaraj
Overview
Explore the profile of V Dhanaraj including associated specialties, affiliations and a list of published articles.
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28
Citations
316
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Recent Articles
1.
Badasso M, Dhanaraj V, Wood S, Cooper J, Blundell T
Acta Crystallogr D Biol Crystallogr
. 2004 Mar;
60(Pt 4):770-2.
PMID: 15039581
Y75N mutant Mucor pusillus pepsin has been overexpressed in yeast, purified and cocrystallized with the iodine-containing human renin inhibitor CP-113972 [(2R,3S]-isopropyl 3-[(L-prolyl-p-iodo-L-phenylalanyl-S-methyl-cysteinyl)amino-4]-cyclohexyl-2-hydroxybutanoate] for X-ray crystallography. Tetragonal complex crystals with space...
2.
von Delft F, Lewendon A, Dhanaraj V, Blundell T, ABELL C, Smith A
Structure
. 2001 May;
9(5):439-50.
PMID: 11377204
Background: Pantothenate synthetase (EC 6.3.2.1) is the last enzyme of the pathway of pantothenate (vitamin B(5)) synthesis. It catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction. Results:...
3.
Blundell T, Burke D, Chirgadze D, Dhanaraj V, Hyvonen M, Innis C, et al.
Biol Chem
. 2000 Nov;
381(9-10):955-9.
PMID: 11076027
We review here signalling complexes that we have defined using X-ray analysis in our laboratory. They include growth factors and their receptors: nerve growth factor (NGF) and its hetero-hexameric 7S...
4.
Chapman M, Smith A, Vailes L, Arruda L, Dhanaraj V, Pomes A
J Allergy Clin Immunol
. 2000 Sep;
106(3):409-18.
PMID: 10984358
Many of the problems associated with using natural allergenic products for allergy diagnosis and treatment can be overcome with use of genetically engineered recombinant allergens. Over the past 10 years,...
5.
Badasso M, Read J, Dhanaraj V, Cooper J, Wood S, Blundell T, et al.
Acta Crystallogr D Biol Crystallogr
. 2000 Aug;
56(Pt 7):915-7.
PMID: 10930843
The vacuolar aspartic proteinase from baker's yeast, saccharopepsin, has been co-crystallized with its natural inhibitor I(A)3, found in the cytosol. The I(A)3-saccharopepsin complex crystals belong to the space group P6(2)22,...
6.
Mizuguchi K, Dhanaraj V, Blundell T, Murzin A
Structure
. 1999 Dec;
7(9):R215-6.
PMID: 10610264
No abstract available.
7.
Pavlovsky A, Williams M, Ye Q, Ortwine D, Purchase 2nd C, White A, et al.
Protein Sci
. 1999 Jul;
8(7):1455-62.
PMID: 10422833
Effective inhibitors of matrix metalloproteinases (MMPs), a family of connective tissue-degrading enzymes, could be useful for the treatment of diseases such as cancer, multiple sclerosis, and arthritis. Many of the...
8.
Castillo R, Mizuguchi K, Dhanaraj V, Albert A, Blundell T, Murzin A
Structure
. 1999 Jun;
7(2):227-36.
PMID: 10368289
Background: Six-stranded beta barrels with a pseudo-twofold axis are found in several proteins. One group comprises a Greek-key structure with all strands antiparallel; an example is the N-terminal domain of...
9.
Srinivasan N, Antonelli M, Jacob G, KORN I, Romero F, Jedlicki A, et al.
Protein Eng
. 1999 Apr;
12(2):119-27.
PMID: 10195283
The catalytic subunit of protein kinase casein kinase 2 (CK2alpha), which has specificity for both ATP and GTP, shows significant amino acid sequence similarity to the cyclin-dependent kinase 2 (CDK2)....
10.
Groves M, Dhanaraj V, Badasso M, Nugent P, Pitts J, Hoover D, et al.
Protein Eng
. 1998 Dec;
11(10):833-40.
PMID: 9862200
In the crystal structure of uncomplexed native chymosin, the beta-hairpin at the active site, known as 'the flap', adopts a different conformation from that of other aspartic proteinases. This conformation...