T L Blundell
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Explore the profile of T L Blundell including associated specialties, affiliations and a list of published articles.
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Articles
243
Citations
11401
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Recent Articles
1.
Leonardo Silvestre H, Asensio J, Blundell T, Bastida A, Bolanos-Garcia V
Int J Biol Macromol
. 2024 Feb;
263(Pt 1):130348.
PMID: 38395274
Enzymes of the GNAT (GCN5-relate N-acetyltransferases) superfamily are important regulators of cell growth and development. They are functionally diverse and share low amino acid sequence identity, making functional annotation difficult....
2.
Sigurdardottir A, Winter A, Sobkowicz A, Fragai M, Chirgadze D, Ascher D, et al.
Chem Sci
. 2018 Aug;
6(11):6147-6157.
PMID: 30090230
The growth/motility factor hepatocyte growth factor/scatter factor (HGF/SF) and its receptor, the tyrosine kinase MET, constitute a signalling system essential for embryogenesis and for tissue/organ regeneration in post-natal life. HGF/SF-MET...
3.
Ruffle S, Donnelly D, Blundell T, Nugent J
Photosynth Res
. 2014 Jan;
34(2):287-300.
PMID: 24408780
A three-dimensional model of the core proteins D1 and D2, including the cofactors, that form the Photosystem II reaction centre of pea (Pisum sativum), has been generated. This model was...
4.
Bailey D, Carpenter E, Coker A, Coker S, Read J, Jones A, et al.
Acta Crystallogr D Biol Crystallogr
. 2012 Apr;
68(Pt 5):541-52.
PMID: 22525752
The analysis reported here describes detailed structural studies of endothiapepsin (the aspartic proteinase from Endothia parasitica), with and without bound inhibitors, and human pepsin 3b. Comparison of multiple crystal structures...
5.
Nunez Miguel R, Sanders J, Chirgadze D, Blundell T, Furmaniak J, Rees Smith B
J Mol Endocrinol
. 2008 Jul;
41(3):145-64.
PMID: 18606720
The crystal structures of the leucine-rich repeat domain (LRD) of the FSH receptor (FSHR) in complex with FSH and the TSH receptor (TSHR) LRD in complex with the thyroid-stimulating autoantibody...
6.
Chelliah V, Blundell T
Biochemistry (Mosc)
. 2005 Oct;
70(8):835-40.
PMID: 16212538
One of Oleg Ptitsyn's most important papers (Shakhnovich, E., Abkevich, V., and Ptitsyn, O. (1996) Nature, 379, 96-98) describes how knowledge of structure and function can be used to understand...
7.
Sanders J, Allen F, Jeffreys J, Bolton J, Richards T, Depraetere H, et al.
Thyroid
. 2005 Aug;
15(7):672-82.
PMID: 16053383
Analysis of nine mouse monoclonal antibodies (mAbs) to the thyrotropin receptor (TSHR) with TSH antagonist activity showed that only one of the mAbs (RSR B2) was an effective antagonist of...
8.
Coxon K, Chakauya E, Ottenhof H, Whitney H, Blundell T, ABELL C, et al.
Biochem Soc Trans
. 2005 Jul;
33(Pt 4):743-6.
PMID: 16042590
Pantothenate (vitamin B5) is a water-soluble vitamin essential for the synthesis of CoA and ACP (acyl-carrier protein, cofactors in energy yielding reactions including carbohydrate metabolism and fatty acid synthesis. Pantothenate...
9.
Bolanos-Garcia V, Beaufils S, Renault A, Grossmann J, Brewerton S, Lee M, et al.
Biophys J
. 2005 Jul;
89(4):2640-9.
PMID: 16040755
BUBR1, a key component of the mitotic spindle checkpoint, is a multidomain protein kinase that is activated in response to kinetochore tension. Although BUB1 and BUBR1 play an important role...
10.
Cubellis M, Caillez F, Blundell T, Lovell S
Proteins
. 2005 Jan;
58(4):880-92.
PMID: 15657931
The polyproline II (PPII) conformation of protein backbone is an important secondary structure type. It is unusual in that, due to steric constraints, its main-chain hydrogen-bond donors and acceptors cannot...