Uthaman Gowthaman
Overview
Explore the profile of Uthaman Gowthaman including associated specialties, affiliations and a list of published articles.
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Articles
31
Citations
866
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Recent Articles
1.
Chen J, Lee D, Gowthaman U
Curr Opin Immunol
. 2024 Sep;
91:102461.
PMID: 39276414
T follicular helper (Tfh) cells help direct the production of antibodies by B cells. In addition to promoting antibody responses to vaccination and infection, Tfh cells have been found to...
2.
Lee D, Krishnaswamy J, Gowthaman U
J Allergy Clin Immunol
. 2022 Sep;
150(5):1050-1052.
PMID: 36174849
No abstract available.
3.
Lee D, Huseby E, Gowthaman U
Trends Parasitol
. 2021 Dec;
38(2):101-103.
PMID: 34953724
Animal models for studying immune responses to Cryptosporidium, a parasite that causes gastrointestinal disease, have been a challenge due to the parasite's poor infectivity in mice. Russler-Germain et al. discovered...
4.
Gowthaman U, Sikder S, Lee D, Fisher C
Curr Opin Immunol
. 2021 Dec;
74:133-139.
PMID: 34952257
T follicular helper (Tfh) cells help orchestrate optimal humoral immunity by helping B cells to produce affinity-matured, class-switched antibodies in germinal centers. Recent studies have unveiled the complexity and heterogeneity...
5.
Chen J, Chow R, Song E, Mao T, Israelow B, Kamath K, et al.
Sci Immunol
. 2021 Dec;
7(68):eabl5652.
PMID: 34914544
T follicular helper (T) cells are the conventional drivers of protective, germinal center (GC)–based antiviral antibody responses. However, loss of T cells and GCs has been observed in patients with...
6.
Gertie J, Zhang B, Liu E, Hoyt L, Yin X, Xu L, et al.
J Allergy Clin Immunol
. 2021 May;
149(1):262-274.
PMID: 34051223
Background: The etiology of food allergy is poorly understood; mouse models are powerful systems to discover immunologic pathways driving allergic disease. C3H/HeJ mice are a widely used model for the...
7.
Chen J, Grassmann J, Gowthaman U, Olyha S, Simoneau T, Berin M, et al.
J Allergy Clin Immunol
. 2020 Jul;
147(2):470-483.
PMID: 32709424
Anaphylaxis is a life-threatening allergic reaction caused by cross-linking of high-affinity IgE antibodies on the surface of mast cells and basophils. Understanding the cellular mechanisms that lead to high-affinity IgE...
8.
Zhang B, Liu E, Gertie J, Joseph J, Xu L, Pinker E, et al.
Sci Immunol
. 2020 May;
5(47).
PMID: 32385053
Immunoglobulin A (IgA) is the dominant antibody isotype in the gut and has been shown to regulate microbiota. Mucosal IgA is also widely believed to prevent food allergens from penetrating...
9.
Gowthaman U, Chen J, Eisenbarth S
J Leukoc Biol
. 2020 Jan;
107(3):409-418.
PMID: 31965637
Allergies to food and environmental antigens have steeply grown to epidemic proportions. IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis. There is now compelling evidence that one...
10.
Gowthaman U, Chen J, Zhang B, Flynn W, Lu Y, Song W, et al.
Science
. 2019 Aug;
365(6456).
PMID: 31371561
Cross-linking of high-affinity immunoglobulin E (IgE) results in the life-threatening allergic reaction anaphylaxis. Yet the cellular mechanisms that induce B cells to produce IgE in response to allergens remain poorly...