David C Jackson
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Explore the profile of David C Jackson including associated specialties, affiliations and a list of published articles.
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117
Citations
2173
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Recent Articles
1.
Premachandre C, Quah P, Tran B, Vincan E, Deliyannis G, Wong C, et al.
Vet Microbiol
. 2024 Dec;
300:110340.
PMID: 39675119
In vitro three-dimensional organoid models simulate key aspects of the structure and function of in vivo organs and have been used to study physiology, host-pathogen interactions, pathogenesis and pharmacodynamics. Although...
2.
Nolan T, Deliyannis G, Griffith M, Braat S, Allen L, Audsley J, et al.
EBioMedicine
. 2023 Nov;
98:104878.
PMID: 38016322
Background: SARS-CoV-2 booster vaccination should ideally enhance protection against variants and minimise immune imprinting. This Phase I trial evaluated two vaccines targeting SARS-CoV-2 beta-variant receptor-binding domain (RBD): a recombinant dimeric...
3.
Deliyannis G, Gherardin N, Wong C, Grimley S, Cooney J, Redmond S, et al.
EBioMedicine
. 2023 May;
92:104574.
PMID: 37148585
Background: The SARS-CoV-2 global pandemic has fuelled the generation of vaccines at an unprecedented pace and scale. However, many challenges remain, including: the emergence of vaccine-resistant mutant viruses, vaccine stability...
4.
Chua B, Sekiya T, Koutsakos M, Nomura N, Rowntree L, Nguyen T, et al.
PLoS Pathog
. 2022 Oct;
18(10):e1010891.
PMID: 36206307
Although antibody-inducing split virus vaccines (SV) are currently the most effective way to combat seasonal influenza, their efficacy can be modest, especially in immunologically-naïve individuals. We investigated immune responses towards...
5.
Tran B, Grimley S, McAuley J, Hachani A, Earnest L, Wong S, et al.
Int J Mol Sci
. 2022 Jan;
23(2).
PMID: 35055020
The global urgency to uncover medical countermeasures to combat the COVID-19 pandemic caused by the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has revealed an unmet need for robust tissue culture...
6.
Occhinegro A, Wong C, Chua B, Jackson D, McKinley M, McAllen R, et al.
Brain Behav Immun
. 2021 Aug;
97:371-375.
PMID: 34333113
The splanchnic anti-inflammatory pathway, the efferent arm of the endogenous inflammatory reflex, has been shown to suppress the acute inflammatory response of rats to systemic lipopolysaccharide (LPS). Here we show...
7.
Shingai M, Nomura N, Sekiya T, Ohno M, Fujikura D, Handabile C, et al.
Vaccine
. 2021 Jun;
39(29):3940-3951.
PMID: 34090697
Current detergent or ether-disrupted split vaccines (SVs) for influenza do not always induce adequate immune responses, especially in young children. This contrasts with the whole virus particle vaccines (WPVs) originally...
8.
Sekiya T, Ohno M, Nomura N, Handabile C, Shingai M, Jackson D, et al.
Viruses
. 2021 Jun;
13(6).
PMID: 34073843
Despite seasonal influenza vaccines having been routinely used for many decades, influenza A virus continues to pose a global threat to humans, causing high morbidity and mortality each year. The...
9.
Hensen L, Illing P, Clemens E, Nguyen T, Koutsakos M, van de Sandt C, et al.
Nat Commun
. 2021 May;
12(1):2931.
PMID: 34006841
Indigenous people worldwide are at high risk of developing severe influenza disease. HLA-A*24:02 allele, highly prevalent in Indigenous populations, is associated with influenza-induced mortality, although the basis for this association...
10.
Systems serology detects functionally distinct coronavirus antibody features in children and elderly
Selva K, van de Sandt C, Lemke M, Lee C, Shoffner S, Chua B, et al.
Nat Commun
. 2021 Apr;
12(1):2037.
PMID: 33795692
The hallmarks of COVID-19 are higher pathogenicity and mortality in the elderly compared to children. Examining baseline SARS-CoV-2 cross-reactive immunological responses, induced by circulating human coronaviruses (hCoVs), is needed to...