Upendra P Dahal
Overview
Explore the profile of Upendra P Dahal including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
17
Citations
211
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Barr J, Lade J, Tran T, Dahal U
Drug Metab Dispos
. 2019 Feb;
47(4):419-423.
PMID: 30733251
It is well recognized that nonspecific binding of a drug within an in vitro assay ( ) can have a large impact on in vitro to in vivo correlations of...
12.
Scott E, Wolf C, Otyepka M, Humphreys S, Reed J, Henderson C, et al.
Drug Metab Dispos
. 2016 Feb;
44(4):576-90.
PMID: 26851242
This symposium summary, sponsored by the ASPET, was held at Experimental Biology 2015 on March 29, 2015, in Boston, Massachusetts. The symposium focused on: 1) the interactions of cytochrome P450s...
13.
Ballard T, Dahal U, Bessire A, Schneider R, Geoghegan K, Vaz A
Rapid Commun Mass Spectrom
. 2015 Oct;
29(22):2175-83.
PMID: 26467230
Rationale: The covalent modification of proteins by toxicants, new chemical entities or drug molecules, either by metabolic activation or the presence of inherently reactive functional groups, is commonly implicated in...
14.
Flanagan M, Abramite J, Anderson D, Aulabaugh A, Dahal U, Gilbert A, et al.
J Med Chem
. 2014 Nov;
57(23):10072-9.
PMID: 25375838
Interest in drugs that covalently modify their target is driven by the desire for enhanced efficacy that can result from the silencing of enzymatic activity until protein resynthesis can occur,...
15.
Dahal U, Obach R, Gilbert A
Chem Res Toxicol
. 2013 Oct;
26(11):1739-45.
PMID: 24164572
Despite several advantages of covalent inhibitors (such as increased biochemical efficiency, longer duration of action on the target, and lower efficacious doses) over their reversible binding counterparts, there is a...
16.
Dahal U, Joswig-Jones C, Jones J
J Med Chem
. 2011 Nov;
55(1):280-90.
PMID: 22087535
Compounds that coordinate to the heme-iron of cytochrome P450 (CYP) enzymes are assumed to increase metabolic stability. However, recently we observed that the type II binding quinoline carboxamide (QCA) compounds...
17.
Dahal U, Jones J, Davis J, Rock D
Drug Metab Dispos
. 2011 Sep;
39(12):2355-60.
PMID: 21937735
Identification and quantification of the metabolites of drugs and drug candidates are routinely performed using liquid chromatography-mass spectrometry (LC-MS). The best practice is to generate a standard curve with the...
18.
Pearson J, Dahal U, Rock D, Peng C, Schenk J, Joswig-Jones C, et al.
Arch Biochem Biophys
. 2011 May;
511(1-2):69-79.
PMID: 21530484
The metabolic stability of a drug is an important property that should be optimized during drug design and development. Nitrogen incorporation is hypothesized to increase the stability by coordination of...