U M Marzec
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Explore the profile of U M Marzec including associated specialties, affiliations and a list of published articles.
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29
Citations
330
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Recent Articles
11.
Runge M, Harker L, Bode C, Ruef J, Kelly A, Marzec U, et al.
Circulation
. 1996 Sep;
94(6):1412-22.
PMID: 8823001
Background: Thrombolytic therapy reduces mortality in patients with acute myocardial infarction, but significant limitations exist with the use of currently available agents. In the present report, we describe the thrombolytic...
12.
Harker L, Marzec U, Hunt P, Kelly A, Tomer A, Cheung E, et al.
Blood
. 1996 Jul;
88(2):511-21.
PMID: 8695799
Thrombopoietin (TPO) is the physiologic Mpl-ligand regulating platelet production. Pegylated human recombinant megakaryocyte growth and development factor (PEG-rHuMGDF), a truncated polypeptide Mpl-ligand derivitized with poly-(ethylene glycol), induces megakaryocyte endoreduplication and...
13.
Harker L, Hunt P, Marzec U, Kelly A, Tomer A, Hanson S, et al.
Blood
. 1996 Mar;
87(5):1833-44.
PMID: 8634430
The primary physiologic regulator of platelet production, Mpl ligand, has recently been cloned and characterized. To define the regulatory role of Mpl ligand on platelet production and function we measured...
14.
Yokoyama T, Kelly A, Marzec U, Hanson S, Kunitada S, Harker L
Circulation
. 1995 Aug;
92(3):485-91.
PMID: 7634464
Background: Since activated factor X (FXa) has a central role in hemostasis and thrombosis, it is an attractive target for antithrombotic strategies. Accordingly, we evaluated the relative antihemostatic and antithrombotic...
15.
Cadroy Y, Hanson S, Kelly A, Marzec U, Evatt B, Kunicki T, et al.
Blood
. 1994 Jun;
83(11):3218-24.
PMID: 8193356
The relative antithrombotic effectiveness of targeting glycoprotein (GP) Ib-dependent versus GPIIb-IIIa-dependent platelet interactions has been determined in baboons by measuring thrombus formation after infusing comparable antihemostatic doses of anti-von Willebrand...
16.
Scharf R, Tomer A, Marzec U, Teirstein P, Ruggeri Z, Harker L
Arterioscler Thromb
. 1992 Dec;
12(12):1475-87.
PMID: 1450179
Fluorescence-activated flow cytometry has been used to investigate platelet activation in blood flowing through atherosclerotic coronary arteries after sustaining mechanical damage induced by percutaneous transluminal angioplasty (PTCA). For flow cytometry,...
17.
Kelly A, Marzec U, Krupski W, Bass A, Cadroy Y, Hanson S, et al.
Blood
. 1991 Mar;
77(5):1006-12.
PMID: 1995089
To determine the role of thrombin in high blood flow, platelet-dependent thrombotic and hemostatic processes we measured the relative antithrombotic and antihemostatic effects in baboons of hirudin, a highly potent...
18.
Krpski W, Bass A, Kelly A, Marzec U, Hanson S, Harker L
Circulation
. 1990 Aug;
82(2):570-7.
PMID: 2372903
Intravascular mechanical support has been proposed as a solution to the frequent occurrence of vascular narrowing and occlusion after transluminal balloon angioplasty or surgical endarterectomy. Although several endovascular stents are...
19.
Savage B, Marzec U, Chao B, Harker L, Maraganore J, Ruggeri Z
J Biol Chem
. 1990 Jul;
265(20):11766-72.
PMID: 2365698
In the present report we describe the platelet-binding characteristics of applaggin and echistatin, potent inhibitors of fibrinogen-dependent platelet aggregation derived from Agkistrodon piscivorus piscivorus and Echis carinatus snake venoms, respectively....
20.
Marzec U, Kelly A, Hanson S, Lasslo A, Harker L
Arteriosclerosis
. 1990 May;
10(3):367-71.
PMID: 2140503
The antithrombotic and antihemostatic effects of the novel antiplatelet compound, alpha, alpha'-bis[3-(N,N-diethylcarbamoyl)piperidino]-p-xylene dihydrobromide (GT-12), were investigated in a baboon model of platelet-dependent thrombosis under high flow conditions. In this model,...