Tze-Chen Hsieh
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Explore the profile of Tze-Chen Hsieh including associated specialties, affiliations and a list of published articles.
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66
Citations
1300
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Recent Articles
11.
Wu J, Oraee A, Doonan B, Pinto J, Hsieh T
Exp Hematol Oncol
. 2016 Sep;
5(1):27.
PMID: 27625902
Background: The Nad(p)h: quinone oxidoreductase (NQO1) confers protection against semiquinones and also elicits oxidative stress. The C609T polymorphism of the NQO1 gene, designated NQO1*2, significantly reduces its enzymatic activity due...
12.
Hsieh T, Wu S, Bennett D, Doonan B, Wu E, Wu J
Oncotarget
. 2016 May;
7(25):38670-38680.
PMID: 27232943
Resveratrol is a polyphenol that has witnessed an unprecedented yearly growth in PubMed citations since the late 1990s. Based on the diversity of cellular processes and diseases resveratrol reportedly affects...
13.
Lee Y, Doonan B, Wu J, Hsieh T
Oncol Rep
. 2016 Apr;
35(6):3735-41.
PMID: 27109601
Aging in humans is a multi-factorial cellular process that is associated with an increase in the risk of numerous diseases including diabetes, coronary heart disease and cancer. Aging is linked...
14.
Ahmed M, Bennett D, Hsieh T, Doonan B, Ahmed S, Wu J
Int J Mol Med
. 2015 Nov;
37(1):3-10.
PMID: 26572802
The one gene-one enzyme hypothesis, first introduced by Beadle and Tatum in the 1940s and based on their genetic analysis and observation of phenotype changes in Neurospora crassa challenged by...
15.
Wang F, Remke M, Bhat K, Wong E, Zhou S, Ramaswamy V, et al.
Oncotarget
. 2015 Jan;
6(5):2709-24.
PMID: 25576913
Over-expression of PDGF receptors (PDGFRs) has been previously implicated in high-risk medulloblastoma (MB) pathogenesis. However, the exact biological functions of PDGFRα and PDGFRβ signaling in MB biology remain poorly understood....
16.
Hsieh T, Lin C, Bennett D, Wu E, Wu J
PLoS One
. 2014 Jun;
9(6):e101070.
PMID: 24968355
Background: AKT plays an important role in the control of cell proliferation and survival. Aberrant activation of AKT frequently occurs in human cancers making it an attractive drug targets and...
17.
Darzynkiewicz Z, Zhao H, Halicka H, Li J, Lee Y, Hsieh T, et al.
Cytometry A
. 2014 Mar;
85(5):386-99.
PMID: 24677687
This review presents the evidence in support of the IGF-1/mTOR/S6K1 signaling as the primary factor contributing to aging and cellular senescence. Reviewed are also specific interactions between mTOR/S6K1 and ROS-DNA...
18.
Hsieh T, Bennett D, Lee Y, Wu E, Wu J
Curr Med Chem
. 2013 Sep;
20(33):4195-202.
PMID: 23992305
To obtain information on anti-prostate cancer (CaP) activities of piceatannol, a metabolite biotransformed from resveratrol by cytochrome P450 CYP1B, CWR22Rv1 cells were incubated with increasing dose of piceatannol. Proliferation and...
19.
Zhou S, Wang F, Hsieh T, Wu J, Wu E
Curr Med Chem
. 2013 Aug;
20(33):4102-8.
PMID: 23931282
In the past 50 years, thalidomide has undergone a remarkable metamorphosis from a notorious drug inducing birth defects into a highly effective therapy for treating leprosy and multiple myeloma. Today,...
20.
Zhou S, Wang F, Wong E, Fonkem E, Hsieh T, Wu J, et al.
Curr Med Chem
. 2013 Aug;
20(33):4095-101.
PMID: 23931281
Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on...