Joseph M Wu
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Explore the profile of Joseph M Wu including associated specialties, affiliations and a list of published articles.
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70
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1656
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Recent Articles
1.
Li J, Qi D, Hsieh T, Huang J, Wu J, Wu E
Pharmacol Ther
. 2021 Jan;
223:107800.
PMID: 33421449
Breast cancer (BCa) is one of the most prevalent malignant tumors affecting women's health worldwide. The recurrence and metastasis of BCa have made it a long-standing challenge to achieve remission-persistent...
2.
Wu Y, Hsieh T, Wu J, Wang X, Christopher J, Pham A, et al.
Biomolecules
. 2020 Aug;
10(9).
PMID: 32842666
Resveratrol, the most widely studied natural phytochemical, has been shown to interact with different target proteins. Previous studies show that resveratrol binds and inhibits DNA polymerases and some other enzymes;...
3.
Hsieh T, Wu J
Int J Mol Sci
. 2020 Mar;
21(5).
PMID: 32143478
Cancer mortality is primarily attributed to metastasis and the resulting compromise of organs secondary to the initial tumor site. Metastasis is a multi-step process in which the tumor cells must...
4.
Hsieh T, Chao H, Wu J
Free Radic Biol Med
. 2020 Jan;
147:212-219.
PMID: 31891751
Topoisomerases are enzymes that catalyze DNA unwinding and scissions to resolve topological entanglements possibly arising during DNA replication/transcription. Chemicals which disrupt or inhibit topoisomerase-mediated DNA unwinding can induce breaks that...
5.
Hsieh T, Wu J
Int J Mol Sci
. 2019 Dec;
20(23).
PMID: 31783532
Programmed cell death ligand 1 (PD-L1) is an immune regulatory protein that facilitates tumor escape from host immune surveillance. In the clinic, tumors with high level of PD-L1 have been...
6.
Wang F, Zhou S, Qi D, Xiang S, Wong E, Wang X, et al.
J Am Chem Soc
. 2019 Jan;
141(8):3613-3622.
PMID: 30689374
The aim of this study is to illuminate a novel therapeutic approach by identifying a functional binding target of salinomycin, an emerging anticancer stem cell (CSC) agent, and to help...
7.
Lucas J, Hsieh T, Halicka H, Darzynkiewicz Z, Wu J
Int J Oncol
. 2018 Aug;
53(4):1469-1480.
PMID: 30066852
Programmed cell death ligand 1 (PD‑L1) expressed in cancer cells interacting with its receptor programmed cell death 1 (PD‑1) expressed in immune cells represents a regulatory axis linked to the...
8.
Dorai T, Shah A, Summers F, Mathew R, Huang J, Hsieh T, et al.
Prostate
. 2018 Jul;
78(15):1181-1195.
PMID: 30009389
In the course of studies aimed at the role of oxidative stress in the development of metastatic potential in the LNCaP-C4-2B prostate cancer progression model system, we found a relative...
9.
Doonan B, Schaafsma E, Pinto J, Wu J, Hsieh T
In Vitro Cell Dev Biol Anim
. 2017 Jun;
53(7):575-578.
PMID: 28646291
Colorectal cancer (CRC) is a major cause of cancer-associated deaths worldwide. Recently, oral administration of resveratrol (trans-3,5,4'-trihydroxystilbene) has been reported to significantly reduce tumor proliferation in colorectal cancer patients, however,...
10.
Mathew R, Huang J, Wu J, Fallon J, Gewitz M
World J Cardiol
. 2017 Jan;
8(12):703-718.
PMID: 28070238
Pulmonary hypertension (PH), a serious disorder with a high morbidity and mortality rate, is known to occur in a number of unrelated systemic diseases. Several hematological disorders such as sickle...