Tyler Laszewski
Overview
Explore the profile of Tyler Laszewski including associated specialties, affiliations and a list of published articles.
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Snapshot
Articles
12
Citations
606
Followers
0
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Recent Articles
1.
Dimitrieva S, Harrison J, Chang J, Piquet M, Mino-Kenudson M, Gabriel M, et al.
Cancer Res Commun
. 2024 Nov;
4(12):3049-3066.
PMID: 39485038
Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.
2.
Janiszewska M, Tabassum D, Castano Z, Cristea S, Yamamoto K, Kingston N, et al.
Nat Cell Biol
. 2024 Mar;
26(5):841.
PMID: 38443568
No abstract available.
3.
Diwanji R, OBrien N, Choi J, Nguyen B, Laszewski T, Grauel A, et al.
Cancer Immunol Res
. 2023 Apr;
11(6):777-791.
PMID: 37040466
High levels of IL1β can result in chronic inflammation, which in turn can promote tumor growth and metastasis. Inhibition of IL1β could therefore be a promising therapeutic option in the...
4.
Jasso G, Jaiswal A, Varma M, Laszewski T, Grauel A, Omar A, et al.
PLoS Biol
. 2022 Jan;
20(1):e3001532.
PMID: 35085231
Chronic inflammation is often associated with the development of tissue fibrosis, but how mesenchymal cell responses dictate pathological fibrosis versus resolution and healing remains unclear. Defining stromal heterogeneity and identifying...
5.
Wang Y, Mohseni M, Grauel A, Estrada Diez J, Guan W, Liang S, et al.
Sci Rep
. 2021 Jan;
11(1):1399.
PMID: 33446805
SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein...
6.
Grauel A, Nguyen B, Ruddy D, Laszewski T, Schwartz S, Chang J, et al.
Nat Commun
. 2020 Dec;
11(1):6315.
PMID: 33298926
Despite the increasing interest in targeting stromal elements of the tumor microenvironment, we still face tremendous challenges in developing adequate therapeutics to modify the tumor stromal landscape. A major obstacle...
7.
Janiszewska M, Tabassum D, Castano Z, Cristea S, Yamamoto K, Kingston N, et al.
Nat Cell Biol
. 2019 Jul;
21(7):879-888.
PMID: 31263265
Most human tumours are heterogeneous, composed of cellular clones with different properties present at variable frequencies. Highly heterogeneous tumours have poor clinical outcomes, yet the underlying mechanism remains poorly understood....
8.
Sceneay J, Goreczny G, Wilson K, Morrow S, DeCristo M, Ubellacker J, et al.
Cancer Discov
. 2019 Jun;
9(9):1208-1227.
PMID: 31217296
Immune checkpoint blockade (ICB) therapy, which targets T cell-inhibitory receptors, has revolutionized cancer treatment. Among the breast cancer subtypes, evaluation of ICB has been of greatest interest in triple-negative breast...
9.
Cremasco V, Astarita J, Grauel A, Keerthivasan S, MacIsaac K, Woodruff M, et al.
Cancer Immunol Res
. 2018 Sep;
6(12):1472-1485.
PMID: 30266714
Cancer-associated fibroblasts (CAFs) are generally associated with poor clinical outcome. CAFs support tumor growth in a variety of ways and can suppress antitumor immunity and response to immunotherapy. However, a...
10.
Castano Z, San Juan B, Spiegel A, Pant A, DeCristo M, Laszewski T, et al.
Nat Cell Biol
. 2018 Aug;
20(9):1084-1097.
PMID: 30154549
Lack of insight into mechanisms governing breast cancer metastasis has precluded the development of curative therapies. Metastasis-initiating cancer cells (MICs) are uniquely equipped to establish metastases, causing recurrence and therapeutic...