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Dynamic Evolution of Fibroblasts Revealed by Single-Cell RNA Sequencing of Human Pancreatic Cancer

Abstract

Pancreatic cancer remains a high unmet medical need. Understanding the interactions between stroma and cancer cells in this disease may unveil new opportunities for therapeutic intervention.

References
1.
Street K, Risso D, Fletcher R, Das D, Ngai J, Yosef N . Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics. BMC Genomics. 2018; 19(1):477. PMC: 6007078. DOI: 10.1186/s12864-018-4772-0. View

2.
Essaghir A, Dif N, Marbehant C, Coffer P, Demoulin J . The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors. J Biol Chem. 2009; 284(16):10334-42. PMC: 2667720. DOI: 10.1074/jbc.M808848200. View

3.
Leavitt T, Hu M, Borrelli M, Januszyk M, Garcia J, Ransom R . Prrx1 Fibroblasts Represent a Pro-fibrotic Lineage in the Mouse Ventral Dermis. Cell Rep. 2020; 33(6):108356. PMC: 7742512. DOI: 10.1016/j.celrep.2020.108356. View

4.
Krishnamurty A, Shyer J, Thai M, Gandham V, Buechler M, Yang Y . LRRC15 myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature. 2022; 611(7934):148-154. PMC: 9630141. DOI: 10.1038/s41586-022-05272-1. View

5.
Kakarla S, Chow K, Mata M, Shaffer D, Song X, Wu M . Antitumor effects of chimeric receptor engineered human T cells directed to tumor stroma. Mol Ther. 2013; 21(8):1611-20. PMC: 3734659. DOI: 10.1038/mt.2013.110. View