Tyler Lahusen
Overview
Explore the profile of Tyler Lahusen including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
1244
Followers
0
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Recent Articles
1.
Muvarak N, Li H, Lahusen T, Galvin J, Kumar P, Pauza C, et al.
Front Med (Lausanne)
. 2022 Dec;
9:1044713.
PMID: 36452901
Clinical Trial Registration: www.clinicaltrials.gov, identifier: NCT03215004.
2.
Liou M, Lahusen T, Li H, Xiao L, Pauza C
Front Immunol
. 2022 Oct;
13:1012051.
PMID: 36275712
Human Vγ9Vδ2 T cells are attractive candidates for cancer immunotherapy due to their potent capacity for tumor recognition and cytolysis of many tumor cell types. However, efforts to deploy clinical...
3.
Li H, Lahusen T, Xiao L, Muvarak N, Blazkova J, Chun T, et al.
Mol Ther Methods Clin Dev
. 2020 May;
17:1048-1060.
PMID: 32462053
Activation, infection, and eventual depletion of human immunodeficiency virus (HIV)-specific cluster of differentiation 4 (CD4) T cells are the crucial pathogenetic events in acquired immunodeficiency syndrome (AIDS). We developed a...
4.
Pauza C, Liou M, Lahusen T, Xiao L, Lapidus R, Cairo C, et al.
Front Immunol
. 2018 Jun;
9:1305.
PMID: 29937769
Human gamma delta T cells have extraordinary properties including the capacity for tumor cell killing. The major gamma delta T cell subset in human beings is designated Vγ9Vδ2 and is...
5.
Masuda T, Xu X, Dimitriadis E, Lahusen T, Deng C
Int J Biol Sci
. 2016 Feb;
12(2):133-43.
PMID: 26884712
The breast cancer associated gene 1 (BRCA1) contains 3 domains: an N-terminal RING domain with ubiquitin E3 ligase activity, C-terminal BRCT protein interaction domain and a central region. RING and...
6.
Jeong S, Xiao C, Finley L, Lahusen T, Souza A, Pierce K, et al.
Cancer Cell
. 2013 Apr;
23(4):450-63.
PMID: 23562301
DNA damage elicits a cellular signaling response that initiates cell cycle arrest and DNA repair. Here, we find that DNA damage triggers a critical block in glutamine metabolism, which is...
7.
Kim H, Vassilopoulos A, Wang R, Lahusen T, Xiao Z, Xu X, et al.
Cancer Cell
. 2011 Oct;
20(4):487-99.
PMID: 22014574
Members of sirtuin family regulate multiple critical biological processes, yet their role in carcinogenesis remains controversial. To investigate the physiological functions of SIRT2 in development and tumorigenesis, we disrupted Sirt2...
8.
Chien C, Kirilyuk A, Li J, Zhang W, Lahusen T, Schmidt M, et al.
J Biol Chem
. 2011 Jun;
286(30):26813-27.
PMID: 21636853
The oncogene amplified in breast cancer 1 (AIB1) is a nuclear receptor coactivator that plays a major role in the progression of various cancers. We previously identified a splice variant...
9.
Xiao C, Kim H, Lahusen T, Wang R, Xu X, Gavrilova O, et al.
J Biol Chem
. 2010 Sep;
285(47):36776-84.
PMID: 20847051
Glucose homeostasis in mammals is mainly regulated by insulin signaling. It was previously shown that SIRT6 mutant mice die before 4 weeks of age, displaying profound abnormalities, including low insulin,...
10.
Shukla V, Coumoul X, Lahusen T, Wang R, Xu X, Vassilopoulos A, et al.
Cell Res
. 2010 Sep;
20(11):1201-15.
PMID: 20820192
Global DNA hypomethylation at CpG islands coupled with local hypermethylation is a hallmark for breast cancer, yet the mechanism underlying this change remains elusive. In this study, we showed that...