Tyler L Dangerfield
Overview
Explore the profile of Tyler L Dangerfield including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
293
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Recent Articles
1.
Fregoso Ocampo R, Bravo J, Dangerfield T, Nocedal I, Jirde S, Alexander L, et al.
Nat Commun
. 2025 Jan;
16(1):457.
PMID: 39774105
Type II CRISPR endonucleases are widely used programmable genome editing tools. Recently, CRISPR-Cas systems with highly compact nucleases have been discovered, including Cas9d (a type II-D nuclease). Here, we report...
2.
Hibshman G, Bravo J, Hooper M, Dangerfield T, Zhang H, Finkelstein I, et al.
Nat Commun
. 2024 Apr;
15(1):3663.
PMID: 38688943
CRISPR-Cas9 is a powerful tool for genome editing, but the strict requirement for an NGG protospacer-adjacent motif (PAM) sequence immediately next to the DNA target limits the number of editable...
3.
Schwartz E, Bravo J, Ahsan M, Macias L, McCafferty C, Dangerfield T, et al.
Nat Commun
. 2024 Apr;
15(1):3324.
PMID: 38637512
CRISPR-Cas are adaptive immune systems in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction. Target RNA cleavage at regular intervals is...
4.
dOelsnitz S, Diaz D, Kim W, Acosta D, Dangerfield T, Schechter M, et al.
Nat Commun
. 2024 Mar;
15(1):2084.
PMID: 38453941
A major challenge to achieving industry-scale biomanufacturing of therapeutic alkaloids is the slow process of biocatalyst engineering. Amaryllidaceae alkaloids, such as the Alzheimer's medication galantamine, are complex plant secondary metabolites...
5.
Dangerfield T, Johnson K
Methods Enzymol
. 2023 May;
685:461-492.
PMID: 37245912
We describe the experimental methods and analysis to define the role of enzyme conformational changes in specificity based on published studies using DNA polymerases as an ideal model system. Rather...
6.
Schwartz E, Bravo J, Ahsan M, Macias L, McCafferty C, Dangerfield T, et al.
Res Sq
. 2023 May;
PMID: 37163044
CRISPR-Cas systems are an adaptive immune system in bacteria and archaea that utilize CRISPR RNA-guided surveillance complexes to target complementary RNA or DNA for destruction. Target RNA cleavage at regular...
7.
Dangerfield T, Paik I, Bhadra S, Johnson K, Ellington A
Nucleic Acids Res
. 2022 Dec;
51(1):488-499.
PMID: 36583345
Loop-mediated isothermal amplification (LAMP) has proven to be easier to implement than PCR for point-of-care diagnostic tests. However, the underlying mechanism of LAMP is complicated and the kinetics of the...
8.
Dangerfield T, Johnson K
ACS Bio Med Chem Au
. 2022 Dec;
2(6):600-606.
PMID: 36570070
Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the virus that causes COVID-19, continues to evolve resistance to vaccines and existing antiviral therapies at an alarming rate, increasing the need for new...
9.
Dangerfield T, Johnson K
J Biol Chem
. 2022 Nov;
299(1):102744.
PMID: 36436560
We show that T7 DNA polymerase (pol) and exonuclease (exo) domains contribute to selective error correction during DNA replication by regulating bidirectional strand transfer between the two active sites. To...
10.
Bravo J, Liu M, Hibshman G, Dangerfield T, Jung K, McCool R, et al.
Nature
. 2022 Mar;
604(7904):E10.
PMID: 35319014
No abstract available.