Tyler Blazey
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Explore the profile of Tyler Blazey including associated specialties, affiliations and a list of published articles.
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22
Citations
794
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Recent Articles
1.
Blazey T, Lee J, Snyder A, Goyal M, Hershey T, Arbelaez A, et al.
bioRxiv
. 2024 Sep;
PMID: 39314314
Multiple studies have shown that hyperglycemia increases the cerebral metabolic rate of glucose (CMRglc) in subcortical white matter. This observation remains unexplained. Using positron emission tomography (PET) and euinsulinaemic glucose...
2.
von Morze C, Blazey T, Shaw A, Spees W, Shoghi K, Ohliger M
Sci Rep
. 2024 Jun;
14(1):14854.
PMID: 38937567
Non-alcoholic steatohepatitis (NASH) is characterized from its early stages by a profound remodeling of the liver microenvironment, encompassing changes in the composition and activities of multiple cell types and associated...
3.
Blazey T, Shaw A, von Morze C
Magn Reson Med
. 2024 Mar;
92(2):772-781.
PMID: 38525658
Purpose: To develop a flexible, vendor-neutral EPI sequence for hyperpolarized C metabolic imaging. Methods: An open-source EPI sequence consisting of a metabolite-specific spectral-spatial RF excitation pulse and a customizable EPI...
4.
von Morze C, Shaw A, Blazey T
Magn Reson Med
. 2024 Mar;
92(2):459-468.
PMID: 38469685
Purpose: To demonstrate hyperpolarization of N-caffeine and report exploratory findings as a potential probe of liver function and perfusion. Methods: An amorphous formulation of [1,3-N]caffeine was developed for hyperpolarization via...
5.
Brier M, Blazey T, Raichle M, Morris J, Benzinger T, Vlassenko A, et al.
Nat Aging
. 2023 Apr;
2(11):991-999.
PMID: 37118084
White matter lesions in cerebral small vessel disease are related to ischemic injury and increase the risk of stroke and cognitive decline. Pathological changes due to cerebral small vessel disease...
6.
Goyal M, Blazey T, Metcalf N, McAvoy M, Strain J, Rahmani M, et al.
Proc Natl Acad Sci U S A
. 2023 Feb;
120(7):e2212256120.
PMID: 36745794
The distribution of brain aerobic glycolysis (AG) in normal young adults correlates spatially with amyloid-beta (Aβ) deposition in individuals with symptomatic and preclinical Alzheimer disease (AD). Brain AG decreases with...
7.
von Morze C, Blazey T, Baeza R, Garipov R, Whitehead T, Reed G, et al.
Magn Reson Med
. 2021 Dec;
87(5):2120-2129.
PMID: 34971459
Purpose: Hyperpolarized (HP) C MRI has enabled real-time imaging of specific enzyme-catalyzed metabolic reactions, but advanced pulse sequences are necessary to capture the dynamic, localized metabolic information. Herein we describe...
8.
Blazey T, Reed G, Garbow J, von Morze C
Tomography
. 2021 Sep;
7(3):466-476.
PMID: 34564302
Although hyperpolarization (HP) greatly increases the sensitivity of C MR, the usefulness of HP in vivo is limited by the short lifetime of HP agents. To address this limitation, we...
9.
von Morze C, Engelbach J, Blazey T, Quirk J, Reed G, Ippolito J, et al.
Magn Reson Med
. 2020 Nov;
85(4):1795-1804.
PMID: 33247884
Purpose: The purpose of this study was to directly compare two isotopic metabolic imaging approaches, hyperpolarized (HP) C MRI and deuterium metabolic imaging (DMI), for imaging specific closely related segments...
10.
von Morze C, Engelbach J, Reed G, Chen A, Quirk J, Blazey T, et al.
Magn Reson Med
. 2020 Nov;
85(4):1814-1820.
PMID: 33179825
Purpose: The purpose of this study was to investigate hyperpolarization and in vivo imaging of [ N]carnitine, a novel endogenous MRI probe with long signal lifetime. Methods: L-[ N]carnitine-d was...