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Anne M Fagan

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Articles 280
Citations 27281
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Recent Articles
1.
Vermunt L, Sutphen C, Dicks E, de Leeuw D, Allegri R, Berman S, et al.
Brain Commun . 2024 Oct; 6(5):fcae357. PMID: 39440304
The grey matter of the brain develops and declines in coordinated patterns during the lifespan. Such covariation patterns of grey matter structure can be quantified as grey matter networks, which...
2.
Wang Q, Schindler S, Chen G, McKay N, McCullough A, Flores S, et al.
Neurology . 2024 Feb; 102(4):e208013. PMID: 38315956
Background And Objectives: Alzheimer disease (AD) is primarily associated with accumulations of amyloid plaques and tau tangles in gray matter, however, it is now acknowledged that neuroinflammation, particularly in white...
3.
Llibre-Guerra J, Iaccarino L, Coble D, Edwards L, Li Y, McDade E, et al.
Brain Commun . 2023 Nov; 5(6):fcad280. PMID: 37942088
Approximately 5% of Alzheimer's disease cases have an early age at onset (<65 years), with 5-10% of these cases attributed to dominantly inherited mutations and the remainder considered as sporadic....
4.
Johnson E, Bian S, Haque R, Carter E, Watson C, Gordon B, et al.
Nat Med . 2023 Aug; 29(8):1979-1988. PMID: 37550416
Alzheimer's disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes-aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary...
5.
Dage J, Eloyan A, Thangarajah M, Hammers D, Fagan A, Gray J, et al.
Alzheimers Dement . 2023 Jul; 19 Suppl 9:S115-S125. PMID: 37491668
Introduction: One goal of the Longitudinal Early Onset Alzheimer's Disease Study (LEADS) is to define the fluid biomarker characteristics of early-onset Alzheimer's disease (EOAD). Methods: Cerebrospinal fluid (CSF) concentrations of...
6.
Phillips B, Western D, Wang L, Timsina J, Sun Y, Gorijala P, et al.
NPJ Parkinsons Dis . 2023 Jul; 9(1):107. PMID: 37422510
Common and rare variants in the LRRK2 locus are associated with Parkinson's disease (PD) risk, but the downstream effects of these variants on protein levels remain unknown. We performed comprehensive...
7.
Ferreiro A, Choi J, Ryou J, Newcomer E, Thompson R, Bollinger R, et al.
Sci Transl Med . 2023 Jun; 15(700):eabo2984. PMID: 37315112
Alzheimer's disease (AD) pathology is thought to progress from normal cognition through preclinical disease and ultimately to symptomatic AD with cognitive impairment. Recent work suggests that the gut microbiome of...
8.
Schultz S, Shirzadi Z, Schultz A, Liu L, Fitzpatrick C, McDade E, et al.
Aging Cell . 2023 Jun; 22(8):e13871. PMID: 37291760
Although pathogenic variants in PSEN1 leading to autosomal-dominant Alzheimer disease (ADAD) are highly penetrant, substantial interindividual variability in the rates of cognitive decline and biomarker change are observed in ADAD....
9.
Luo J, Ma Y, Agboola F, Grant E, Morris J, McDade E, et al.
Neurology . 2023 May; 101(2):e164-e177. PMID: 37202169
Background And Objectives: White matter hyperintensities (WMH) correlate with Alzheimer disease (AD) biomarkers cross-sectionally and modulate AD pathogenesis. Longitudinal changes have been reported for AD biomarkers, including concentrations of CSF...
10.
Barthelemy N, Saef B, Li Y, Gordon B, He Y, Horie K, et al.
Nat Aging . 2023 Apr; 3(4):391-401. PMID: 37117788
Cerebrospinal fluid (CSF) amyloid-β peptide (Aβ)42/Aβ40 and the concentration of tau phosphorylated at site 181 (p-tau181) are well-established biomarkers of Alzheimer's disease (AD). The present study used mass spectrometry to...