Tsutomu Shimada
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Explore the profile of Tsutomu Shimada including associated specialties, affiliations and a list of published articles.
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Articles
152
Citations
2535
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Recent Articles
1.
Mizuno S, Takabayashi M, Makihara H, Ogai K, Tsukui K, Ito Y, et al.
J Pharm Health Care Sci
. 2024 Dec;
10(1):80.
PMID: 39696707
Background: In the dose titration of transdermal fentanyl to prevent unrelieved pain, it is important to consider not only dose adjustment, but also the titration period, which is influenced by...
2.
Mizuno S, Gake S, Takabayashi M, Ito Y, Sanada H, Sugimoto N, et al.
Drug Metab Pharmacokinet
. 2024 Dec;
60:101035.
PMID: 39693856
A retrospective study and an animal study were conducted to investigate factors affecting the transdermal fentanyl dose to achieve adequate pain relief in patients switched from other opioids. In the...
3.
Ishida N, Katsura A, Takagaki K, Arakawa H, Shimada T, Mizuno S, et al.
BMC Oral Health
. 2024 Aug;
24(1):881.
PMID: 39095752
Background: Hyposalivation is treated using oral cholinergic drugs; however, systemic side effects occasionally lead to discontinuation of treatment. We aimed to investigate the effects of transdermal pilocarpine on the salivary...
4.
Makihara H, Maezawa M, Kaiga K, Satake T, Muto M, Tsunoda Y, et al.
Xenobiotica
. 2024 Apr;
54(5):226-232.
PMID: 38646717
Various cytochrome P450 enzymes (CYPs) that contribute to drug metabolism are expressed in the skin. However, variation among individuals in CYP expression profiles is not well-understood.To investigate CYPs related to...
5.
Muhammad H, Shimada T, Fujita A, Sai Y
Drug Metab Pharmacokinet
. 2024 Mar;
55:100995.
PMID: 38447327
Pazopanib exhibits pH-dependent solubility and its absorption depends primarily on the stomach pH. Significant decrease of pazopanib absorption by coadministration with proton pump inhibitors in clinical situation need to be...
6.
Shimada T, Kawakami D, Fujita A, Yamamoto R, Hara S, Ito K, et al.
J Pharm Health Care Sci
. 2024 Jan;
10(1):5.
PMID: 38191469
Background: Therapeutic drug monitoring (TDM) systems generally use either liquid chromatography/tandem mass spectrometry (LC-MS/MS) or immunoassay, though both methodologies have disadvantages. In this study, we aimed to evaluate whether a...
7.
Ishida N, Oshima Y, Katsura A, Imamura R, Arakawa H, Shimada T, et al.
Biol Pharm Bull
. 2023 Dec;
46(12):1805-1809.
PMID: 38044099
Transdermal scopolamine applied to the postauricular area is used to treat drooling. We investigated the duration of action of scopolamine ointment and the effect of the application site on drug...
8.
Sumiya K, Shogenji M, Ikenaga Y, Ogawa Y, Hirako K, Fujita A, et al.
J Stroke Cerebrovasc Dis
. 2023 Oct;
32(12):107419.
PMID: 37839304
Objectives: Stroke patients frequently exhibit loss of independence of urination, and their lower urinary tract symptoms change with the phase of stroke. However, it is unclear whether switching prescribed drugs...
9.
Nagayoshi H, Murayama N, Kim V, Kim D, Takenaka S, Yamazaki H, et al.
Chem Res Toxicol
. 2023 Oct;
36(11):1778-1788.
PMID: 37783573
Naringenin, an initial synthesized flavanone in various plant species, is further utilized for production of many biologically active flavonoids, e.g., apigenin, eriodictyol, and genistein, by various plant enzymes including cytochrome...
10.
Ito Y, Nakade J, Seki A, Gabata R, Okazaki M, Nakanuma S, et al.
J Pharm Health Care Sci
. 2023 Apr;
9(1):15.
PMID: 37122008
Background: High-flow continuous hemodiafiltration (HF-CHDF) combines diffusive and convective solute removal and is employed for artificial liver adjuvant therapy. However, there is no report on dosage planning of vancomycin (VCM)...