Tsutomu Matsubara
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Explore the profile of Tsutomu Matsubara including associated specialties, affiliations and a list of published articles.
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59
Citations
2066
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Recent Articles
1.
Arai T, Hayashi E, Maeda S, Matsubara T, Fujii H, Shinohara K, et al.
Nat Commun
. 2025 Mar;
16(1):1950.
PMID: 40082404
Compensatory pancreatic islet hyperplasia is an adaptive response to increased systemic insulin demand, although factors meditating this response remain poorly understood. Here, we show that a liver-derived secreted protein, Neuregulin1α,...
2.
Yuasa H, Matsubara T, Urushima H, Daikoku A, Ikenaga H, Kadono C, et al.
Am J Physiol Cell Physiol
. 2025 Jan;
328(3):C757-C775.
PMID: 39871537
The activation of hepatic stellate cells (HSCs) from a quiescent state is a cause of liver fibrosis and a therapeutic target. HSCs are resident mesenchymal cells located in the space...
3.
Urushima H, Matsubara T, Qiongya G, Daikoku A, Takayama M, Kadono C, et al.
Am J Physiol Gastrointest Liver Physiol
. 2024 Sep;
327(6):G741-G753.
PMID: 39316687
Cirrhosis, which represents the end stage of liver fibrosis, remains a life-threatening condition without effective treatment. Therefore, prevention of the progression of liver fibrosis through lifestyle habits such as diet...
4.
Vu H, Nguyen V, Ikenaga H, Matsubara T
Biomedicines
. 2024 Aug;
12(8).
PMID: 39200340
Metabolic dysfunction-associated steatotic liver disease/steatohepatitis (MASLD/MASH) is a major disease worldwide whose effective treatment is challenging. Peroxisome proliferator-activated receptors (PPARs) belong to the nuclear receptor superfamily and function as ligand-activated...
5.
Kawamura E, Matsubara T, Kawada N
Cancers (Basel)
. 2023 Aug;
15(15).
PMID: 37568808
Intrahepatic cholangiocarcinoma (CC) accounts for approximately 20% of all biliary tract cancer (BTC) cases and 10-15% of all primary liver cancer cases. Many patients are diagnosed with unresectable BTC, and,...
6.
Urushima H, Matsubara T, Miyakoshi M, Kimura S, Yuasa H, Yoshizato K, et al.
Am J Physiol Gastrointest Liver Physiol
. 2023 Jan;
324(3):G219-G230.
PMID: 36719093
In cirrhosis, several molecular alterations such as resistance to apoptosis could accelerate carcinogenesis. Recently, mechanotransduction has been attracting attention as one of the causes of these disturbances. In patients with...
7.
Huu Hoang T, Sato-Matsubara M, Yuasa H, Matsubara T, Thuy L, Ikenaga H, et al.
Sci Adv
. 2022 Sep;
8(39):eabo5525.
PMID: 36170363
Intracellular gap (iGap) formation in liver sinusoidal endothelial cells (LSECs) is caused by the destruction of fenestrae and appears under pathological conditions; nevertheless, their role in metastasis of cancer cells...
8.
Kawamura E, Matsubara T, Daikoku A, Deguchi S, Kinoshita M, Yuasa H, et al.
FEBS Open Bio
. 2022 Sep;
12(12):2122-2135.
PMID: 36114826
Cholangiocarcinoma (CC) has a poor prognosis and different driver genes depending on the site of onset. Intrahepatic CC is the second-most common liver cancer after hepatocellular carcinoma, and novel therapeutic...
9.
Okina Y, Sato-Matsubara M, Kido Y, Urushima H, Daikoku A, Kadono C, et al.
Antioxid Redox Signal
. 2022 Sep;
38(7-9):463-479.
PMID: 36112670
Cell-cell interactions between hepatocytes (Hep) and other liver cells are key to maintaining liver homeostasis. Cytoglobin (CYGB), expressed exclusively by hepatic stellate cells (HSC), is essential in mitigating mitochondrial oxidative...
10.
Yoshizato K, Taira T, Sato-Matsubara M, Sekiguchi S, Yabunaka Y, Kira Y, et al.
J Biochem
. 2022 Jul;
172(4):205-216.
PMID: 35792074
Saliva contributes to the innate immune system, which suggests that it can prevent SARS-CoV-2 entry. We studied the ability of healthy salivary proteins to bind to angiotensin-converting enzyme 2 (ACE2)...