Trine Nygaard Jorgensen
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Explore the profile of Trine Nygaard Jorgensen including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
191
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Recent Articles
1.
Fullerton Stoier J, Jorgensen T, Sparso T, Rasmussen H, Kumar V, Newman A, et al.
medRxiv
. 2023 Sep;
PMID: 37693601
Affective or mood disorders are a leading cause of disability worldwide. The serotonergic system has been heavily implicated in the complex etiology and serves as a therapeutic target. The serotonin...
2.
Forsingdal A, Jorgensen T, Olsen L, Werge T, Didriksen M, Nielsen J
Biol Psychiatry
. 2018 Aug;
85(1):13-24.
PMID: 30144930
The diagnosis of schizophrenia rests on clinical criteria that cannot be assessed in animal models. Together with absence of a clear underlying pathology and understanding of what causes schizophrenia, this...
3.
Rahbek-Clemmensen T, Bay T, Eriksen J, Gether U, Jorgensen T
J Biol Chem
. 2014 Jun;
289(33):23004-23019.
PMID: 24973209
The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space. The molecular and cellular mechanisms controlling SERT levels in...
4.
Kumar V, Rahbek-Clemmensen T, Billesbolle C, Jorgensen T, Gether U, Newman A
ACS Med Chem Lett
. 2014 Jun;
5(6):696-9.
PMID: 24944746
Novel rhodamine-labeled ligands, based on (S)-citalopram, were synthesized and evaluated for uptake inhibition at the human serotonin, dopamine, and norepinephrine transporters (hSERT, hDAT, and hNET, respectively) and for binding at...
5.
Jorgensen T, Christensen P, Gether U
Neurochem Int
. 2014 Jan;
73:107-12.
PMID: 24462583
The serotonin transporter (SERT) terminates serotonergic signaling and enables refilling of synaptic vesicles by mediating reuptake of serotonin (5-HT) released into the synaptic cleft. The molecular and cellular mechanisms controlling...
6.
Rickhag M, Owens W, Winkler M, Strandfelt K, Rathje M, Sorensen G, et al.
J Biol Chem
. 2013 Jul;
288(38):27534-27544.
PMID: 23884410
The dopamine transporter (DAT) is responsible for sequestration of extracellular dopamine (DA). The psychostimulant amphetamine (AMPH) is a DAT substrate, which is actively transported into the nerve terminal, eliciting vesicular...
7.
Zhang P, Jorgensen T, Loland C, Newman A
Bioorg Med Chem Lett
. 2012 Nov;
23(1):323-6.
PMID: 23168018
A novel fluorescent ligand was synthesized as a high-affinity, high specificity probe for visualizing the serotonin transporter (SERT). The rhodamine fluorophore was extended from an aniline substitution on the 5-position...
8.
Eriksen J, Bjorn-Yoshimoto W, Jorgensen T, Newman A, Gether U
J Biol Chem
. 2010 Jun;
285(35):27289-27301.
PMID: 20551317
The dopamine transporter (DAT) mediates reuptake of released dopamine and is the target for psychostimulants, such as cocaine and amphetamine. DAT undergoes marked constitutive endocytosis, but little is known about...
9.
Eriksen J, Jorgensen T, Gether U
J Neurochem
. 2010 Jan;
113(1):27-41.
PMID: 20085610
The dopamine transporter (DAT) plays a key role in regulating dopaminergic signalling in the brain by mediating rapid clearance of dopamine from the synaptic clefts. The psychostimulatory actions of cocaine...