Trevor Wilkinson
Overview
Explore the profile of Trevor Wilkinson including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
258
Followers
0
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Recent Articles
1.
Stephens A, Wilkinson T
BioDrugs
. 2024 Oct;
38(6):769-794.
PMID: 39453540
Complex integral membrane proteins, which are embedded in the cell surface lipid bilayer by multiple transmembrane spanning polypeptides, encompass families of proteins that are important target classes for drug discovery....
2.
Sampson J, Cannon D, Duan J, Epstein J, Sergeeva A, Katsamba P, et al.
J Mol Biol
. 2024 Jun;
436(16):168640.
PMID: 38844044
Computational free energy-based methods have the potential to significantly improve throughput and decrease costs of protein design efforts. Such methods must reach a high level of reliability, accuracy, and automation...
3.
Wilburn D, Miserlis D, Fletcher E, Papoutsi E, Ismaeel A, Bradley C, et al.
Sci Rep
. 2024 Jun;
14(1):12609.
PMID: 38824194
Peripheral artery disease (PAD) is characterized by varying severity of arterial stenosis, exercise induced claudication, malperfused tissue precluding normal healing and skeletal muscle dysfunction. Revascularization interventions improve circulation, but post-reperfusion...
4.
Bradley C, Fletcher E, Wilkinson T, Ring A, Ferrer L, Miserlis D, et al.
EXCLI J
. 2024 May;
23:523-533.
PMID: 38741727
Peripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading...
5.
Sampson J, Cannon D, Duan J, Epstein J, Sergeeva A, Katsamba P, et al.
bioRxiv
. 2024 May;
PMID: 38712280
Computational free energy-based methods have the potential to significantly improve throughput and decrease costs of protein design efforts. Such methods must reach a high level of reliability, accuracy, and automation...
6.
Fletcher E, Miserlis D, Sorokolet K, Wilburn D, Bradley C, Papoutsi E, et al.
Transl Res
. 2023 May;
260:17-31.
PMID: 37220835
Peripheral artery disease (PAD) causes an ischemic myopathy contributing to patient disability and mortality. Most preclinical models to date use young, healthy rodents with limited translatability to human disease. Although...
7.
Scrivner O, Fletcher E, Hoffmann C, Li F, Wilkinson T, Miserlis D, et al.
J Am Coll Surg
. 2023 Jan;
236(4):588-598.
PMID: 36656266
Background: Peripheral arterial disease (PAD) causes leg muscle damage due to inadequate perfusion and increases cardiovascular events and mortality 2- to 3-fold. It is unclear if PAD is a biomarker...
8.
Dodd R, Schofield D, Wilkinson T, Britton Z
Methods
. 2020 May;
180:111-126.
PMID: 32422249
Complex integral membrane proteins, which are embedded in the cell surface lipid bilayer by multiple transmembrane spanning helices, encompass families of proteins which are important target classes for drug discovery....
9.
Williams W, Linley J, Jones C, Shibata Y, Snijder A, Button J, et al.
Pain
. 2019 May;
160(9):1989-2003.
PMID: 31045747
P2X4 is a ligand-gated ion channel implicated in neuropathic pain. Drug discovery efforts targeting P2X4 have been unsuccessful largely because of the difficulty in engineering specificity and selectivity. Here, we...
10.
Britton Z, London T, Carrell J, Dosanjh B, Wilkinson T, Bowen M, et al.
Protein Eng Des Sel
. 2019 Feb;
31(10):389-398.
PMID: 30753634
Membrane proteins play key roles in the evolution of numerous diseases and as a result have become the most dominant class of targets for therapeutic intervention. However, their poor expression...