Trent Hinkle
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Explore the profile of Trent Hinkle including associated specialties, affiliations and a list of published articles.
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11
Citations
190
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Recent Articles
1.
Staniak M, Huang T, Figueroa-Navedo A, Kohler D, Choi M, Hinkle T, et al.
Bioinformatics
. 2025 Jan;
41(3).
PMID: 39888862
Motivation: Bottom-up mass spectrometry-based proteomics studies changes in protein abundance and structure across conditions. Since the currency of these experiments are peptides, i.e. subsets of protein sequences that carry the...
2.
Villa S, Dwivedi P, Stahl A, Hinkle T, Rose C, Kirkpatrick D, et al.
Nat Commun
. 2024 Aug;
15(1):6873.
PMID: 39127721
Ribosomes are regulated by evolutionarily conserved ubiquitination/deubiquitination events. We uncover the role of the deubiquitinase OTUD6 in regulating global protein translation through deubiquitination of the RPS7/eS7 subunit on the free...
3.
Li J, Purser N, Liwocha J, Scott D, Byers H, Steigenberger B, et al.
Mol Cell
. 2024 Feb;
84(7):1304-1320.e16.
PMID: 38382526
Cullin-RING ligases (CRLs) ubiquitylate specific substrates selected from other cellular proteins. Substrate discrimination and ubiquitin transferase activity were thought to be strictly separated. Substrates are recognized by substrate receptors, such...
4.
Calses P, Pham V, Guarnaccia A, Choi M, Verschueren E, Bakker S, et al.
Mol Cell Proteomics
. 2023 Jan;
22(2):100496.
PMID: 36640924
Transcriptional enhanced associate domain family members 1 to 4 (TEADs) are a family of four transcription factors and the major transcriptional effectors of the Hippo pathway. In order to activate...
5.
Kohler D, Tsai T, Verschueren E, Huang T, Hinkle T, Phu L, et al.
Mol Cell Proteomics
. 2022 Dec;
22(1):100477.
PMID: 36496144
Liquid chromatography coupled with bottom-up mass spectrometry (LC-MS/MS)-based proteomics is increasingly used to detect changes in posttranslational modifications (PTMs) in samples from different conditions. Analysis of data from such experiments...
6.
Cantley J, Ye X, Rousseau E, Januario T, Hamman B, Rose C, et al.
Nat Commun
. 2022 Nov;
13(1):6814.
PMID: 36357397
The mammalian SWItch/Sucrose Non-Fermentable (SWI/SNF) helicase SMARCA4 is frequently mutated in cancer and inactivation results in a cellular dependence on its paralog, SMARCA2, thus making SMARCA2 an attractive synthetic lethal...
7.
Tortosa E, Sengupta Ghosh A, Li Q, Wong W, Hinkle T, Sandoval W, et al.
EMBO J
. 2022 May;
41(14):e110155.
PMID: 35611591
Mitogen-activated protein kinases (MAPKs) drive key signaling cascades during neuronal survival and degeneration. The localization of kinases to specific subcellular compartments is a critical mechanism to locally control signaling activity...
8.
Keerthivasan S, Senbabaoglu Y, Martinez-Martin N, Husain B, Verschueren E, Wong A, et al.
Immunity
. 2021 Jul;
54(7):1511-1526.e8.
PMID: 34260887
Myeloid cells encounter stromal cells and their matrix determinants on a continual basis during their residence in any given organ. Here, we examined the impact of the collagen receptor LAIR1...
9.
Maculins T, Verschueren E, Hinkle T, Choi M, Chang P, Chalouni C, et al.
Elife
. 2021 Jun;
10.
PMID: 34085925
Defective autophagy is strongly associated with chronic inflammation. Loss-of-function of the core autophagy gene increases risk for Crohn's disease in part by enhancing innate immunity through myeloid cells such as...
10.
Gitlin A, Heger K, Schubert A, Reja R, Yan D, Pham V, et al.
Nature
. 2020 Sep;
587(7833):275-280.
PMID: 32971525
Mutations in the death receptor FAS or its ligand FASL cause autoimmune lymphoproliferative syndrome, whereas mutations in caspase-8 or its adaptor FADD-which mediate cell death downstream of FAS and FASL-cause...