Tracy L Young-Pearse
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Explore the profile of Tracy L Young-Pearse including associated specialties, affiliations and a list of published articles.
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57
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2189
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Recent Articles
1.
Lee H, Pearse 2nd R, Lish A, Pan C, Augur Z, Terzioglu G, et al.
Glia
. 2025 Feb;
PMID: 39901616
Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants are associated with genes highly expressed in astrocytes. However, the contribution of genetic risk within astrocytes...
2.
Clark K, White A, Paslawski W, Alexander K, Peng S, Young-Pearse T, et al.
Mol Biol Cell
. 2025 Jan;
36(2):br4.
PMID: 39745872
Parkinson disease (PD) is the second most common neurodegenerative disease, characterized by both motor and cognitive features. Motor symptoms primarily involve midbrain dopaminergic neurons, while cognitive dysfunction involves cortical neurons....
3.
Lee H, Pearse R, Lish A, Pan C, Augur Z, Terzioglu G, et al.
bioRxiv
. 2024 Aug;
PMID: 39211227
Reactive astrocytes are associated with Alzheimer's disease (AD), and several AD genetic risk variants are associated with genes highly expressed in astrocytes. However, the contribution of genetic risk within astrocytes...
4.
White A, Clark K, Alexander K, Ramalingam N, Young-Pearse T, Dettmer U, et al.
NPJ Parkinsons Dis
. 2024 May;
10(1):107.
PMID: 38773105
Alpha-synuclein (αS)-rich Lewy bodies and neurites in the cerebral cortex correlate with the presence of dementia in Parkinson disease (PD) and Dementia with Lewy bodies (DLB), but whether αS influences...
5.
Hsieh Y, Augur Z, Arbery M, Ashour N, Barrett K, Pearse 2nd R, et al.
Alzheimers Dement
. 2024 Mar;
20(4):2952-2967.
PMID: 38470006
Background: Impairment of the ubiquitin-proteasome system (UPS) has been implicated in abnormal protein accumulation in Alzheimer's disease. It remains unclear if genetic variation affects the intrinsic properties of neurons that...
6.
Bartosch A, Youth E, Hansen S, Wu Y, Buchanan H, Kaufman M, et al.
J Neurosci
. 2023 Dec;
44(3).
PMID: 38050142
ZCCHC17 is a putative master regulator of synaptic gene dysfunction in Alzheimer's disease (AD), and ZCCHC17 protein declines early in AD brain tissue, before significant gliosis or neuronal loss. Here,...
7.
Terzioglu G, Young-Pearse T
Mol Neurodegener
. 2023 Nov;
18(1):89.
PMID: 38017562
Recent genetic studies on Alzheimer's disease (AD) have brought microglia under the spotlight, as loci associated with AD risk are enriched in genes expressed in microglia. Several of these genes...
8.
Chou V, Pearse 2nd R, Aylward A, Ashour N, Taga M, Terzioglu G, et al.
Nat Commun
. 2023 Nov;
14(1):7552.
PMID: 38016942
Microglia and neuroinflammation play an important role in the development and progression of Alzheimer's disease (AD). Inositol polyphosphate-5-phosphatase D (INPP5D/SHIP1) is a myeloid-expressed gene genetically-associated with AD. Through unbiased analyses...
9.
Nguyen L, Wei Z, Silva M, Barberan-Soler S, Zhang J, Rabinovsky R, et al.
Nat Commun
. 2023 Nov;
14(1):7575.
PMID: 37989753
MicroRNAs (miRNAs) regulate fundamental biological processes by silencing mRNA targets and are dysregulated in many diseases. Therefore, miRNA replacement or inhibition can be harnessed as potential therapeutics. However, existing strategies...
10.
Lee H, Aylward A, Pearse 2nd R, Lish A, Hsieh Y, Augur Z, et al.
Cell Rep
. 2023 Aug;
42(8):112994.
PMID: 37611586
SORL1 is implicated in the pathogenesis of Alzheimer's disease (AD) through genetic studies. To interrogate the roles of SORL1 in human brain cells, SORL1-null induced pluripotent stem cells (iPSCs) were...