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Toshimitsu Kawate

Explore the profile of Toshimitsu Kawate including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 2454
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Recent Articles
1.
Henze E, Ehrlich J, Robertson J, Gelsleichter E, Kawate T
Proc Natl Acad Sci U S A . 2024 Dec; 121(51):e2411898121. PMID: 39671183
Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of adenosine triphosphate (ATP) from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the...
2.
Henze E, Ehrlich J, Robertson J, Kawate T
bioRxiv . 2024 Jun; PMID: 38915727
Pannexin 1 (Panx1) constitutes a large pore channel responsible for the release of ATP from apoptotic cells. Strong evidence indicates that caspase-mediated cleavage of the C-terminus promotes the opening of...
3.
Henze E, Burkhardt R, Fox B, Schwertfeger T, Gelsleichter E, Michalski K, et al.
bioRxiv . 2023 Nov; PMID: 37961151
In addition to its role as cellular energy currency, adenosine triphosphate (ATP) serves as an extracellular messenger that mediates diverse cell-to-cell communication. Compelling evidence supports that ATP is released from...
4.
Nguyen P, Greentree W, Kawate T, Linder M
Front Physiol . 2023 Apr; 14:1167094. PMID: 37035671
Protein -acylation is a reversible lipid post-translational modification that allows dynamic regulation of processes such as protein stability, membrane association, and localization. Palmitoyltransferase ZDHHC9 (DHHC9) is one of the 23...
5.
Murrell-Lagnado R, Kawate T
Methods Mol Biol . 2022 Jul; 2510:253-264. PMID: 35776329
Cholesterol dynamically regulates P2X7 receptor function in both physiological and pathological conditions. Studies suggest that cholesterol suppresses P2X7 receptor activity through direct binding or through indirect effects on the biophysical...
6.
Syrjanen J, Michalski K, Kawate T, Furukawa H
J Mol Biol . 2021 Apr; 433(17):166994. PMID: 33865869
Membrane transport is a fundamental means to control basic cellular processes such as apoptosis, inflammation, and neurodegeneration and is mediated by a number of transporters, pumps, and channels. Accumulating evidence...
7.
Michalski K, Syrjanen J, Henze E, Kumpf J, Furukawa H, Kawate T
Elife . 2020 Feb; 9. PMID: 32048993
Pannexins are large-pore forming channels responsible for ATP release under a variety of physiological and pathological conditions. Although predicted to share similar membrane topology with other large-pore forming proteins such...
8.
Mann N, Kause F, Henze E, Gharpure A, Shril S, Connaughton D, et al.
Am J Hum Genet . 2019 Nov; 105(6):1286-1293. PMID: 31708116
Congenital anomalies of the kidney and urinary tract (CAKUT) are the most common cause of chronic kidney disease in the first three decades of life, and in utero obstruction to...
9.
Michalski K, Henze E, Nguyen P, Lynch P, Kawate T
J Gen Physiol . 2018 Nov; 150(12):1758-1768. PMID: 30377218
Pannexins are a family of ATP release channels important for physiological and pathological processes like blood pressure regulation, epilepsy, and neuropathic pain. To study these important channels in vitro, voltage...
10.
Karasawa A, Kawate T
Bio Protoc . 2017 Oct; 7(17). PMID: 28966946
The P2X7 receptor is an extracellular ATP-gated ion channel found only in eukaryotes (Bartlett ., 2014). Due to its unique properties among P2X receptors, such as formation of a large...