Toshimasa Itoh
Overview
Explore the profile of Toshimasa Itoh including associated specialties, affiliations and a list of published articles.
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82
Citations
627
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Recent Articles
1.
Kyoya T, Ishida H, Saitoh T, Itoh T
Org Biomol Chem
. 2025 Jan;
23(8):1901-1908.
PMID: 39815739
The development of covalent drugs, particularly those utilizing Michael acceptors, has garnered significant attention in recent pharmaceutical research due to the ability of such molecules to irreversibly inhibit protein function....
2.
Yano T, Yamada T, Ishida H, Ohashi N, Itoh T
RSC Adv
. 2024 Apr;
14(18):12416.
PMID: 38633483
[This corrects the article DOI: 10.1039/D4RA00437J.].
3.
Yano T, Yamada T, Isida H, Ohashi N, Itoh T
RSC Adv
. 2024 Feb;
14(10):6542-6547.
PMID: 38390509
Inspired by the chemical reactivity of apalutamide, we have developed an efficient method for N-terminal cysteine bioconjugation with 2-cyanopyridine derivatives. Systematic investigations of various 2-cyanopyridines revealed that 2-cyanopyridines with electron-withdrawing...
4.
Hirai T, Aoyama T, Tsuji Y, Itoh T, Matsumoto Y, Iwamoto T
Br J Clin Pharmacol
. 2023 Nov;
90(3):828-836.
PMID: 37953511
Aims: Genotype-guided dosing algorithms can explain about half of the interindividual variability in prothrombin time-international normalized ratio (PT-INR) under warfarin treatment. This study aimed to refine a published kinetic-pharmacodynamic model...
5.
Ishida Y, Goto E, Haga Y, Kubo M, Itoh T, Kasai C, et al.
Sci Total Environ
. 2023 May;
890:164475.
PMID: 37257625
Bacterial cytochrome P450 monooxygenase P450BM3 is a promising enzyme to provide novel substrate specificity and enhanced enzymatic activity. The wild type (WT) has been shown to metabolize the widely distributed...
6.
Kojima H, Yanagi R, Higuchi E, Yoshizawa M, Shimodaira T, Kumagai M, et al.
J Med Chem
. 2023 Mar;
66(7):4827-4839.
PMID: 36994595
Covalent ligands are generally filtered out of chemical libraries used for high-throughput screening, because electrophilic functional groups are considered to be pan-assay interference compounds (PAINS). Therefore, screening strategies that can...
7.
Ito T, Miwa C, Haga Y, Kubo M, Itoh T, Yamamoto K, et al.
Chemosphere
. 2022 Sep;
308(Pt 2):136349.
PMID: 36084836
Chiral polychlorinated biphenyls (PCBs) have atropisomers that have different axial chiralities and exist as racemic mixtures. However, biochemical processes often result in the unequal accumulation of these atropisomers in organisms....
8.
Inui H, Ito T, Miwa C, Haga Y, Kubo M, Itoh T, et al.
Environ Sci Technol
. 2022 Jul;
56(14):10204-10215.
PMID: 35801261
Although polychlorinated biphenyls (PCBs) were commercially banned half a century ago, contamination of the environment and organisms by PCBs is still observed. PCBs show high persistence and bioaccumulation, resulting in...
9.
Hirai T, Kasai H, Takahashi M, Uchida S, Akai N, Hanada K, et al.
Biol Pharm Bull
. 2022 Jul;
45(7):948-954.
PMID: 35786602
Some population pharmacokinetic models for amiodarone (AMD) did not incorporate N-desethylamiodarone (DEA) concentration. Glucocorticoids activate CYP3A4 activity, metabolizing AMD. In contrast, CYP3A4 activity may decrease under inflammation conditions. However, direct...
10.
Yabu M, Haga Y, Itoh T, Goto E, Suzuki M, Yamazaki K, et al.
Sci Total Environ
. 2022 May;
837:155848.
PMID: 35568185
Cytochrome P450 (CYP) monooxygenases play critical roles in determining the toxicity of polychlorinated biphenyls (PCBs) in mammals. Hydroxylation of PCBs by these enzymes leads to increased water solubility, promoting the...