Tony T Huang
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Explore the profile of Tony T Huang including associated specialties, affiliations and a list of published articles.
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54
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2771
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Recent Articles
1.
Gokbuget D, Goehring L, Boileau R, Lenshoek K, Huang T, Blelloch R
Cell Rep
. 2025 Feb;
44(2):115272.
PMID: 39908143
Mammalian genomes replicate in a cell-type-specific order during the S phase, correlated to transcriptional activity, histone modifications, and chromatin structure. The causal relationships between these features and DNA replication timing...
2.
Nam M, Xia W, Mir A, Jerrett A, Spinelli J, Huang T, et al.
Nat Metab
. 2024 Nov;
6(12):2338-2353.
PMID: 39592843
Cancer cells often experience nutrient-limiting conditions because of their robust proliferation and inadequate tumour vasculature, which results in metabolic adaptation to sustain proliferation. Most cancer cells rapidly consume glucose, which...
3.
Goehring L, Keegan S, Lahiri S, Xia W, Kong M, Jimenez-Sainz J, et al.
Nat Commun
. 2024 Jun;
15(1):4716.
PMID: 38830843
BRCA2 is a tumor suppressor protein responsible for safeguarding the cellular genome from replication stress and genotoxicity, but the specific mechanism(s) by which this is achieved to prevent early oncogenesis...
4.
Goehring L, Huang T, Smith D
Annu Rev Genet
. 2023 Aug;
57:157-179.
PMID: 37552891
Transcription and replication both require large macromolecular complexes to act on a DNA template, yet these machineries cannot simultaneously act on the same DNA sequence. Conflicts between the replication and...
5.
Hu H, Khatri L, Santacruz M, Church E, Moore C, Huang T, et al.
Front Mol Neurosci
. 2023 Jul;
16:1179209.
PMID: 37456526
Classic experiments with peripheral sympathetic neurons established an absolute dependence upon NGF for survival. A forgotten problem is how these neurons become resistant to deprivation of trophic factors. The question...
6.
Coleman K, Yin Y, Lui S, Keegan S, Fenyo D, Smith D, et al.
Nat Commun
. 2022 Apr;
13(1):1740.
PMID: 35365626
The deubiquitinase USP1 is a critical regulator of genome integrity through the deubiquitylation of Fanconi Anemia proteins and the DNA replication processivity factor, proliferating cell nuclear antigen (PCNA). Uniquely, following...
7.
Lv Z, Cano K, Jia L, Drag M, Huang T, Olsen S
Front Chem
. 2022 Feb;
9:819165.
PMID: 35186898
The emergence of severe acute respiratory syndrome (SARS-CoV-2) in 2019 marked the third occurrence of a highly pathogenic coronavirus in the human population since 2003. As the death toll surpasses...
8.
Hu H, Srinivas K, Wang S, Chao M, Lionnet T, Mohr I, et al.
EMBO Rep
. 2021 Nov;
23(2):e53543.
PMID: 34842321
Single-cell RNA sequencing (scRNA-seq) is a powerful technique for dissecting the complexity of normal and diseased tissues, enabling characterization of cell diversity and heterogeneous phenotypic states in unprecedented detail. However,...
9.
Goehring L, Huang T
Cell Rep Med
. 2021 Oct;
2(9):100402.
PMID: 34622238
amplification is an oncogenic driver for many gynecologic cancers and is associated with poor patient outcomes. In this issue, Xu et al. identify a combination therapy that is responsive to...
10.
A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease
Patchett S, Lv Z, Rut W, Bekes M, Drag M, Olsen S, et al.
Cell Rep
. 2021 Sep;
36(13):109754.
PMID: 34547223
The SARS-CoV-2 papain-like protease (PLpro) is a target for antiviral drug development. It is essential for processing viral polyproteins for replication and functions in host immune evasion by cleaving ubiquitin...