Peter Tonzi
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Explore the profile of Peter Tonzi including associated specialties, affiliations and a list of published articles.
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10
Citations
495
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Recent Articles
1.
Yin Y, Lee W, Gupta D, Xue H, Tonzi P, Borowiec J, et al.
Mol Cell
. 2021 Sep;
81(20):4243-4257.e6.
PMID: 34473946
Mammalian cells use diverse pathways to prevent deleterious consequences during DNA replication, yet the mechanism by which cells survey individual replisomes to detect spontaneous replication impediments at the basal level,...
2.
Jia W, Kim S, Scalf M, Tonzi P, Millikin R, Guns W, et al.
J Biol Chem
. 2021 Aug;
297(3):101049.
PMID: 34375640
Fused in sarcoma (FUS) encodes an RNA-binding protein with diverse roles in transcriptional activation and RNA splicing. While oncogenic fusions of FUS and transcription factor DNA-binding domains are associated with...
3.
Lee W, Yin Y, Morten M, Tonzi P, Gwo P, Odermatt D, et al.
Nat Commun
. 2021 May;
12(1):2525.
PMID: 33953191
Guanine-rich DNA sequences occur throughout the human genome and can transiently form G-quadruplex (G4) structures that may obstruct DNA replication, leading to genomic instability. Here, we apply multi-color single-molecule localization...
4.
Lui S, Keegan S, Tonzi P, Kahli M, Chen Y, Chalhoub N, et al.
Nat Protoc
. 2021 Jan;
16(2):1193-1218.
PMID: 33442052
The ability to monitor DNA replication fork directionality at the genome-wide scale is paramount for a greater understanding of how genetic and environmental perturbations can impact replication dynamics in human...
5.
Sviderskiy V, Blumenberg L, Gorodetsky E, Karakousi T, Hirsh N, Alvarez S, et al.
Mol Cell
. 2020 Nov;
80(4):682-698.e7.
PMID: 33152268
Knowledge of fundamental differences between breast cancer subtypes has driven therapeutic advances; however, basal-like breast cancer (BLBC) remains clinically intractable. Because BLBC exhibits alterations in DNA repair enzymes and cell-cycle...
6.
Sanchez A, de Vivo A, Tonzi P, Kim J, Huang T, Kee Y
PLoS Genet
. 2020 Mar;
16(3):e1008524.
PMID: 32142505
Common fragile sites (CFSs) are breakage-prone genomic loci, and are considered to be hotspots for genomic rearrangements frequently observed in cancers. Understanding the underlying mechanisms for CFS instability will lead...
7.
Tonzi P, Huang T
DNA Repair (Amst)
. 2019 Apr;
78:20-26.
PMID: 30954011
DNA replication stress, defined as the slowing or stalling of replication forks, is considered an emerging hallmark of cancer and a major contributor to genomic instability associated with tumorigenesis (Macheret...
8.
Chen Y, Keegan S, Kahli M, Tonzi P, Fenyo D, Huang T, et al.
Nat Struct Mol Biol
. 2019 Jan;
26(1):67-77.
PMID: 30598550
Although DNA replication is a fundamental aspect of biology, it is not known what determines where DNA replication starts and stops in the human genome. We directly identified and quantitatively...
9.
Tonzi P, Yin Y, Lee C, Rothenberg E, Huang T
Elife
. 2018 Nov;
7.
PMID: 30422114
DNA replication stress is often defined by the slowing or stalling of replication fork progression leading to local or global DNA synthesis inhibition. Failure to resolve replication stress in a...
10.
Perry J, Kiezun A, Tonzi P, Van Allen E, Carter S, Baca S, et al.
Proc Natl Acad Sci U S A
. 2014 Dec;
111(51):E5564-73.
PMID: 25512523
Osteosarcoma is the most common primary bone tumor, yet there have been no substantial advances in treatment or survival in three decades. We examined 59 tumor/normal pairs by whole-exome, whole-genome,...