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Tongzheng Liu

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Articles 62
Citations 1870
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Recent Articles
1.
Zhao F, Cai C, Gao H, Moon J, Christyani G, Qin S, et al.
Nucleic Acids Res . 2025 Mar; 53(5). PMID: 40052822
The TopBP1-ATR axis is critical for maintaining genomic stability during DNA replication stress, yet the precise regulation of TopBP1 in replication stress responses remains poorly understood. In this study, we...
2.
Wen Y, Yang X, Li S, Huang L, Chen J, Tan L, et al.
MedComm (2020) . 2025 Feb; 6(3):e70103. PMID: 39968498
Colorectal cancer (CRC) is among the most prevalent and deadly cancers worldwide. The Yes-associated protein 1 (YAP1) is frequently dysregulated in cancers, contributing to cancer stemness, chemoresistance, and cancer-related death....
3.
Huang L, Wen Y, Guo Q, Zhang C, Yang X, Li M, et al.
Cell Death Dis . 2025 Jan; 16(1):27. PMID: 39827153
The aberrant upregulation of Yes-associated protein 1 (YAP1) in a variety of solid cancers contributes to tumor progression and poor clinical outcomes, rendering it an appealing therapeutic target. However, effective...
4.
Sun J, Gu M, Peng L, Guo J, Chen P, Wen Y, et al.
J Am Chem Soc . 2024 Dec; 147(1):372-383. PMID: 39703105
Molecular glues are promising protein-degrading agents that hold great therapeutic potential but face significant challenges in rational design, effective synthesis, and precise targeting of tumor sites. In this study, we...
5.
Wen Y, Wang H, Yang X, Zhu Y, Li M, Ma X, et al.
Nat Commun . 2024 Nov; 15(1):10088. PMID: 39572526
Activating mutations in NRAS account for 15-20% of melanoma, yet effective anti-NRAS therapies are still lacking. In this study, we unveil the casein kinase 1δ (CK1δ) as an uncharacterized regulator...
6.
Lai T, Li F, Xiang L, Liu Z, Li Q, Cao M, et al.
Transl Cancer Res . 2024 Oct; 13(9):4786-4799. PMID: 39430830
Background: Globally, liver cancer as one of the most frequent fatal malignancies, hits hard and fast. And the lack of effective treatments for liver hepatocellular carcinoma (LIHC), activates the researchers...
7.
Ren J, Liu T, You L, Hu M, Zhu J, Wang X, et al.
Heliyon . 2024 Jul; 10(13):e34082. PMID: 39071603
Parkinson's disease (PD) is a severe neurodegenerative disease that disturbs human health. In the laboratory researches about PD, the mice model induced by intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) was widely...
8.
Li M, Zhang L, Guan T, Huang L, Zhu Y, Wen Y, et al.
Cancer Lett . 2024 May; 595:216987. PMID: 38815798
Triple-negative breast cancer (TNBC) is a highly lethal malignancy with limited therapy options. Aberrant metabolism, a key hallmark of human cancers, plays a crucial role in tumor progression, therapeutic responses...
9.
Liang J, Yao N, Deng B, Li J, Jiang Y, Liu T, et al.
J Cell Physiol . 2024 Mar; 239(5):e31237. PMID: 38468464
GINS1 regulates DNA replication in the initiation and elongation phases and plays an important role in the progression of various malignant tumors. However, the role of GINS1 in hepatocellular carcinoma...
10.
Ma X, Wan R, Wen Y, Liu T, Song Y, Zhu Y
Exp Cell Res . 2023 Dec; 434(1):113864. PMID: 38040050
Metastasis is the primary cause of cancer-related deaths and remains poorly understood. Deubiquitinase OTU domain containing 4 (OTUD4) has been reported to regulate antiviral immune responses and resistance to radio-...